Full Description
A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical conditions, and future perspectives. The overall goal is to facilitate the translation of basic research on stem cells to clinical applications. The properties of stem cells from various sources are reviewed and the advantages and disadvantages of each for clinical use are discussed. Modifying stem cell properties through preconditioning strategies using physical, chemical, genetic, and molecular manipulation to improve cell survival, increase cell differentiation potential, enhance production of paracrine factors, and facilitate homing to the site of injury or disease upon transplantation are reviewed. Various routes of stem cell administration and dosing, and the duration of effects, are explored. Individual chapters are written by experts in the field and focus on the use of stem cells in treating various degenerative diseases, autoimmune diseases, wound healing, cardiovascular disease, spinal cord injury, oral and dental diseases, and skeletal disorders. Finally, experts in the regulatory arena discuss mechanisms used in different countries for approving the use of stem cells to treat diseases and many common issues that are typically encountered while seeking approval for this class of therapeutic agent.
Contents
Part 1 Principles and Concepts
1. What Can We Learn From This Book?
Travis J. Block, David D. Dean and Xiao-Dong Chen
2. Features of Mesenchymal Stem Cells
Stan Gronthos
3. Maintenance and Culture of MSCs
Milos Marinkovic, David D. Dean and Xiao-Dong Chen
4. Manufacturing Mesenchymal Stromal Cell Banks
Jamie Hoover and Patrick J. Hanley
Part 2 Promises and Challenges of MSC-Based Therapies
5. Mesenchymal Stem Cell-Based Therapy of Osteoarthritis: Current Clinical Developments and Future Therapeutic Strategies
Maxime Ruiz, Marie Maumus, Christian Jorgensen and Daniele Noel
6. Mesenchymal Stem Cell Therapy in Graft Versus Host Disease
Shivaprasad Manjappa, Rizwan Romee and Armin Rashidi
7. Systemic Lupus Erythematosus
Dandan Wang and Lingyun Sun
8. Mesenchymal Stem Cell-Based Therapies for Repair and Regeneration of Skin Wounds
Shanmugasundaram Natesan, Randolph Stone, Rodney K. Chan and Robert J. Christy
9. Myocardial Infarction
Natalia Rozwadowska and Maciej Kurpisz
10. Bone Marrow Mesenchymal Stem Cells as a New Therapeutic Approach for Diabetes Mellitus
Joseph Kim, John Z. Q. Luo and Luguang Luo
11. Mesenchymal Stem Cell-Based Therapy for Chronic Kidney Disease
Maria V. Irazabal, LaTonya J. Hickson and Alfonso Eirin
12. Promises and Challenges of MSC-Based Therapies: Parkinson Disease and Parkinsonism
Ashley Aaroe and Claire Henchcliffe
13. Spinal Cord Injury
K. A. Ruppert, S. D. Olson and C. S. Cox
14. Stem Cell-Based Restoration of Salivary Gland Function
Olivia N. Tran, Hanzhou Wang, David D. Dean, Xiao-Dong Chen and Chih-Ko Yeh
15. Tooth and Dental Pulp Regeneration
Bei Li, Chen Xi and Yan Jin
Part 3: Future Perspectives
16. MSCs as Biological Drugs
Thekkeparambil Chandrabose Srijaya, Sandhya Sriram, Noor Hayaty Abu Kasim and Shigeki Sugii
17. Mesenchymal Stem Cell-Derived Products for Tissue Repair and Regeneration
Anand Srinivasan, Michelle Lynn Fults, Peter Supronowicz, Roberto Esquivel and Rogelio Zamilpa
18. Use of MSCs in Antiaging Strategies
Travis J. Block, David D. Dean and Xiao-Dong Chen
19. Regulatory Developments for Nonhematopoietic Stem Cell Therapeutics: Perspectives From the EU, the USA, Japan, China, India, Argentina, and Brazil
Achim Rosemann, Gabriela Bortz and Federico Vasen
