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Full Description
Protein Modificomics: From Modifications to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins, including discussions on diseases involving PTMs, such as Alzheimer's, Huntington's, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome and OFC10. The book also discusses the role PTMs play in plant physiology and the production of medicinally important primary and secondary metabolites. The understanding of PTMs in plants helps us enhance the production of these metabolites without greatly altering the genome, providing robust eukaryotic systems for the production and isolation of desired products without considerable downstream and isolation processes.
Contents
1. Emerging roles of posttranslational modifications in biological processes and their implications in associated diseases
2. Clinical perspective of posttranslational modifications
3. Phosphorylation and acetylation of proteins as posttranslational modification: implications in human health and associated diseases
4. Protein modifications and lifestyle disorders
5. Ubiquitin mediated posttranslational modification of proteins involved in various signaling diseases
6. Improving pharmacological efficacy of protein pharmaceuticals by glycosylation
7. Posttranslational modification in human therapeutics heterologously produced in plant host expression systems
8. Protein modification in plants in response to abiotic stress
9. Posttranslational modifications associated with cancer and their therapeutic implications
10. Nonenzymatic posttranslational protein modifications: mechanisms and associated disease pathologies
11. Protein covalent modification by homocysteine: consequences and clinical implications
12. Posttranslational modifications in algae: role in stress response and biopharmaceutical production
13. Protein glycosylation: an important tool in diagnosis or early detection of diseases
