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Full Description
Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches.
This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies.
Contents
1. Introduction
SECTION I: NON-CODING RNAs: FINE-TUNING CANCER
2. miRNA and Cancer: A Deadly Liaison?
3. Alteration of MicroRNA Biogenesis Pathways in Cancers
4. MicroRNAs In Exosomes in Cancer
5. Circulating miRNAs Incresaing the Risk of Cancer
6. Long Noncoding RNAs as Cancer Biomarkers
7. The Balancing Act: Understanding MicroRNA and Competing Endogenous RNA Regulation in Cancer
8. PIWI-Interacting RNAs (piRNAs) and Cancer
9. Transfer RNA in Cancer
10. Dynamic Regulation of tRNA Modifications in Cancer
11. Circular RNA: A Novel Noncoding RNA in Cancer
12. Antisense RNA and Cancer
13. Implication of Other Noncoding RNAs in Cancer
SECTION 2: GENETIC DYSREGULATION OF NON-CODING RNA IN CANCER
14. Noncoding RNA Alterations in Cancer Molecular Pathways
15. Genetic Alteration of MicroRNA Affecting Cancer Pathways
16. Genetic Variations of Long Noncoding RNAs in Cancer
SECTION 3: EPIGENETIC EFFECT ON CANCER THROUGH NON-CODING RNAs
17. Cross Talk Between Noncoding RNAs and DNA Methylation and Demethylation in Cancer
18. Noncoding RNAs Act as a Chromatin Scaffold of Histone Modification Complexes in Cancer
19. Heterochromatin Modulation and PcG Control of Gene Expression Medicated by Noncoding RNA in Cancer
20. Epigenetic Control of MicroRNA Expression and Cancer
21. Implications of Long Noncoding RNAs in Cancer Epigenetics
SECTION 4: THERAPEUTIC IMPLICATIONS OF NON-CODING RNA IN CANCER
22. Long Noncoding RNAs: Insight Into Their Roles in Normal and Cancer Stem Cells
23. Clinical Relevance, Prognostic Potential, and Therapeutic Strategies of Noncoding RNAs in Cancer
24. Noncoding RNAs: Novel Targets in Anticancer Drug Development
SECTION 5: BIOINFORMATICS' DETECTION OF NON-CODING RNA IN CANCER
25. Cancer Noncoding RNA Discovery Through High-Throughput Sequencing
26. Noncoding RNAs as a Cauce of Cancer: Evidence From Genome-Wide Association Studies and Reverse Genetics
27. A Comparative Evaluation of Emerging Databases and Tools for Cancer Noncoding RNAs
28. Future Directions and Challenges Involved in Cancer Noncoding RNomics
