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Full Description
Dyneins: The Biology of Dynein Motors, Second Edition, offers a broad view of dyneins from structure, composition and organization, to biology of dynein function in both cytoplasm and cilia. As the second book in a pair on this topic, these works provide an overview of dyneins, from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics and the consequences of defects for human biology, disease and development. This second edition is extensively revised, with coverage expanded from 24 to 42 chapters.
Much of the expanded coverage occurs in Volume Two on dynein dysfunction and disease, such as the role of dynein and cancer, while Volume One covers the history and evolution of dyneins, dyneins in ciliary biology and cytoplasmic dynein biology.
Contents
I. History and Evolution
1. Discovery of dynein and its properties: a personal account
2. Origins of cytoplasmic dynein
3. The evolutionary biology of dyneins
II. Dyneins in Ciliary Biology
4. Cytoplasmic preassembly and trafficking of axonemal dyneins
5. Composition and assembly of axonemal dyneins
6. Organization of dyneins in the axoneme
7. Genetic approaches to axonemal dynein function in Chlamydomonas and other organisms
8. Regulatory mechanics of outer arm dynein motors
9. Control of axonemal inner dynein arms
10. Ciliary and flagellar motility and the nexin-dynein regulatory complex
11. Regulation of dynein-driven ciliary and flagellar movement
12. Dynein-mediated photobehavioral responses in Chlamydomonas
13. Dynein and intraflagellar transport
III. Cytoplasmic Dynein Biology
14. Cytoplasmic dynein function defined by subunit composition
15. Regulation of cytoplasmic dynein motility
16. Insights into cytoplasmic dynein function and regulation from fungal genetics
17. Role of dynactin in dynein-mediated motility
18. Role of cytoplasmic dynein and dynactin in mitotic checkpoint silencing
19. Cytoplasmic dynein during mitosis
20. Dynein and dynactin at microtubule plus ends
21. Drosophila cytoplasmic dynein: mutations, tools and developmental functions
