Full Description
Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer's Disease, Parkinson's Disease, Motor Neuron Disease, Autism and lysosomal storage disorders.
This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases.
Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics.
Contents
1. Biometals and Alzheimer's Disease
2. Copper in Alzheimer's Disease
3. The Role of Selenium in Neurodegenerative Diseases
4. Does HFE Genotype Impact Macrophage Phenotype in Disease Process and Therapeutic Response?
5. Chemical Elements and Oxidative Status in Neuroinflammation
6. Metals and Neuroinflammation
7. Metals and Prions: Twenty Years of Mining the Awe
8. Manganese and Neurodegeneration
9. Zinc in Autism
10. Metals and Motor Neuron Disease
11. Metals and Lysosomal Storage Disorders
12. Developmental Exposure to Metals and its Contribution to Age-Related Neurodegeneration
13. Metal Biology Associated with Huntington's Disease
14. Metal-Binding to Amyloid-β Peptide: Coordination, Aggregation, and Reactive Oxygen Species Production
15. Metals and Mitochondria in Neurodegeneration
16. Metal Transporters in Neurodegeneration
17. Metal Imaging in the Brain
18. Metalloregulation of Protein Clearance: New Therapeutic Avenues for Neurodegenerative Diseases
19. Metals and Autophagy in Neurotoxicity
20. An Overview of Multifunctional Metal Chelators as Potential Treatments for Neurodegenerative Diseases
21. Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases
