Full Description
Adenosine Receptors in Neurodegenerative Diseases covers the role of adenosine receptors in brain function, also focusing on related methodologies and perspectives in therapeutics. The book provides an up-to-date overview by the best specialists in the field, helping readers consider the importance of adenosine and expand the global impact and visibility of adenosine research in the CNS field.
Chapters include adenosine biology and signaling, gene regulation, control of motor function, and novel adenosine-based therapies in the CNS. It is an ideal resource for researchers, advanced graduate students, clinicians, and industry scientists working in the fields of clinical neuroscience and molecular and cellular neuroscience.
Contents
Section I. Physiology
1. Physiology: Adenosine receptor biology in the CNS
Michael Freissmuth and Karl-Norbert Klotz
2. Physiology: Adenosine signaling throughout development
Stefania Zappettini and Christophe Bernard
3. Physiology: Influence of adenosine on synaptic excitability
Detlev Boison, Raquel B. Dias, Traci Plumb, Sofia Cristóvão-Ferreira and Ana Sebastiao
4. Physiology: Regulation of synaptic transmission by adenosine at the neuromuscular junction
Paula Pousinha and Joaquim A. Ribeiro
5. Physiology: Gene-regulation of adenosine A2A receptors in the central nervous system
Marta Barrachina, Chien-Yu Lin and Yijuang Chern
Section II. Pathology
6. Pathology: Sleep, adenosine, and neurodegeneration
Theresa Bjorness and Robert W. Greene
7. Pathology: neuronal vs glial cell contribution to adenosine A2A receptor-induced neurodegeneration
Antonella Ferrante, Maria Teresa Tebano, Alberto Martire, Maria Rosaria Domenici and Patrizia Popoli
8. Pathology: Adenosine and oxygen/glucose deprivation in the brain
Felicita Pedata, Ilaria Dettori, Irene Fusco, Elisabetta Coppi, Anna Maria Pugliese and Alessia Melani
9. Pathology: Adenosine receptors and memory disorders
Alexandre de Mendonca, David Blum and Jonathan D. Geiger
10. Pathology: Control of motor function by adenosine A2A receptors in Parkinson and Huntington disease
Annalisa Pinna, Jadwiga Wardas, Maria Rosaria Domenici, Patrizia Popoli, Giovanni Cossu and Micaela Morelli
11. Pathology: Adenosine receptors oligomers in Parkinson disease
Victor Fernández-Dueñas and Francisco Ciruela
12. Pathology: Adenosine control of striatal function - implications for the treatment of apathy in basal ganglia disorders
Sergi Ferré
