Full Description
New Therapeutics for Traumatic Brain Injury: Prevention of Secondary Brain Damage and Enhancement of Repair and Regeneration explores traumatic brain injury (TBI), a major cause of death and disability throughout the world. The delayed nature of the secondary injury phase suggests that there is a therapeutic window for pharmacological interventions or other approaches to prevent progressive tissue damage and improve functional outcomes. It is now apparent that therapeutic interventions should entail both protective and repair/regeneration strategies depending on the phase of brain injury.
This book describes emerging experimental strategies for the treatment of TBI, including new anti-inflammatory or anti-apoptotic therapeutics that limit brain damage, and novel or repurposed drugs that enhance repair or regeneration of the brain after injury.
Contents
Part I. Interventional Therapies for TBI Previously or Currently in Phase 3 Clinical Trials
1. Why Did the Phase III Clinical Trials for Progesterone in TBI Fail? An Analysis of Three Potentially Critical Factors
2. Hypothermia for Traumatic Brain Injury: Current Evidence and Future Directions
3. The Future of TBI: Hyperbaric Oxygen as a Primary Therapeutic Approach
Part II. Repurposing FDA Approved Drugs for TBI Treatment
4. Erythropoietin and Its Derivatives: Mechanisms of Neuroprotection and Challenges in Clinical Translation
5. Atorvastatin in the Treatment of Traumatic Brain Injury
6. The Application of Glibenclamide in Traumatic Brain Injury
7. Perispinal Etanercept for Traumatic Brain Injury
Part III. Interventional Drugs for TBI in Phase 1-2 Clinical Trials
8. Nitric Oxide Synthase Inhibitors in Traumatic Brain Injury
9. Management of Paroxysmal Sympathetic Hyperactivity After Traumatic Brain Injury
Part IV. Interventional Drugs for TBI in Preclinical Development
10. The Use of Estrogen for the Treatment of Traumatic Brain Injury
11. Voltage-Gated Calcium Channel Blockers for the Treatment of Traumatic Brain Injury
12. 5-Lipoxygenase-Activating Protein Inhibitors: Promising Drugs for Treating Acute and Chronic Neuroinflammation Following Brain Injury
13. Carbonyl Scavenging as an Antioxidant Neuroprotective Strategy for Acute Traumatic Brain Injury
14. TrkB Receptor Agonist 7,8-Dihydroxyflavone and Its Therapeutic Potential for Traumatic Brain Injury
15. Ceftriaxone Treatment of TBI
Part V. Drugs for TBI Rehabilitation
16. Memantine: A Safe and Tolerable NMDA Antagonist with Potential Benefits in Traumatic Brain Injury
17. Interventional Drugs for TBI Rehabilitation of Cognitive Impairment: The Cholinesterase Inhibitor Rivastigmine
18. Docosahexaenoic Acid and Omega 3 Fatty Acids
19. Treatment of Mood Disorders Following Traumatic Brain Injury
