Full Description
In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body's ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body's own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications.
Contents
1. Fundamentals of In Situ Tissue Regeneration
Sang Jin Lee, James J. Yoo and Antony Atala
2. Stem Cell Homing
Mariusz Z. Ratajczak and Ahmed A. Ismail
3. Immunology - Host Responses to Biomaterials
John D. Jackson
4. Foreign Body Reaction and Stem Cell Responses
Ashwin Nair and Liping Tang
5. Roles of endogenous growth factors and small peptides in in situ tissue regeneration
Suna Kim, Hyun Sook Hong and Youngsook Son
6. Small molecules: Controlling cell fate and function
Baisong Lu and Anthony Atala
7. Small RNA Delivery for In Situ Tissue Regeneration
NaJung Kim, James J. Yoo, Anthony Atala, and Sang Jin Lee
8. Micro and Nano Topographical cues guiding biomaterial host response
Deepak M. Kalaskar and Feras Alshomer
9. Mechanobiology and Mechanotherapy in Tissue Engineering
Rei Ogawa
10. A biomimetic strategy to design biomaterials for in situ tissue regeneration
Ji Hyun Kim and Sang Jin Lee
11. Impact of Matrix Dynamic Properties on Stem Cell Viability
Marc B. Taraban1, Yuqi Li, Katherine A. Joyner, Joseph P. Stains and Yihua B. Yu
12. Cell-free Scaffolds for In situ Tissue Regeneration
Seung Hun Park, Bo Keun Lee, James Yoo, Sang Jin Lee and Moon Suk Kim
13. In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design
T. Konrad Rajab and Harald Ott
14. Synovial Joint: In Situ Regeneration of Osteochondral and Fibrocartilaginous Tissues by Homing of Endogenous Cells
Solaiman Tarafder and Chang H. Lee
15. Bioengineered strategies for tendon regeneration
Ana I. Gonçalves, Márcia T. Rodrigues, Rui L. Reis and Manuela E. Gomes
16. Volumetric Muscle Repair In Situ
Lindsey E. Shapiroa, Ji Hyun Kima, In Kap Ko, Sang Jin Lee, James J. Yoo and Anthony Atalaa
17. Mending The Heart Through In Situ Cardiac Regeneration
Jeremy Choon Meng Teo, Selwa Mokhtar Boularaoui, Noaf Salah Ali AlWahab and Nicolas Christoforou
18. Skin Wound Healing - Skin Regeneration with Pharmacological Mobilized Stem Cells
Zhaoli Sun and George Melville Williams
19. In situ renal regeneration
Hung-Jen Wang, Sang Jin Lee, Anthony Atala and James J. Yoo
20. Regulatory Aspects: regulation aspects of cell-free biomaterial implants
Nan Zhang, Alexander Baume, Richard Payne, Julie Allickson
21. Business Perspective - case study: commercialized cell-free cardiovascular implant
Alexander Sheehy, Byron Lambert and Richard Rapoza
