Full Description
Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies.
The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues.
The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment.
Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples.
Contents
Preface
Gary Felsenfeld
1. Introduction and History
Suming Huang
2. Histone Modifications
Michael Litt
3. Genomic imprinting in mammals - memories of generations past
Nora Engel
4. Polycomb and trithorax factors in transcriptional and epigenetic regulation
Priscilla Nga Ieng Lau and Chi Wai Eric So
5. Chromatin dynamics and genome organization in development and disease
Changwang Deng, Bhavita Patel, Yangqiu Li and Suming Huang
6. ncRNA function in chromatin organization
Keith E. Giles, Jessica L. Woolnough and Blake Atwood
7. Epigenetic Gene Regulation and Stem Cell Function
Aissa Benyoucef and Marjorie Brand
8. Epigenetic Inheritance
Benjamin B. Mills, Christine M. McBride and Nicole C. Riddle
9. Transgenerational epigenetic regulation by environmental factors in human diseases
Yuanyuan Li
10. Identification of intergenic long non-coding RNA by deep sequencing
Gangqing Hu and Keji Zhao
11. Regulation of erythroid cell differentiation by transcription factors, chromatin structure alterations, and noncoding RNA
Alex Xiucheng Fan, Mir A. Hossain, Jared Stees, Ekaterina Gavrilova and Jörg Bungert
12. Genetically altered cancer epigenome
Ming Tang, Huacheng Luo and Jianrong Lu
13. Long non-coding RNAs and carcinogenesis
Félix Recillas-Targa
14. Epigenetics of physiological and premature aging
Shrestha Ghosh and Zhongjun Zhou
15. Epigenetic Effects of Environment and Diet
Jason O. Brant and Thomas P. Yang
16. Epigenetic control of stress-induced apoptosis
Lei Zhou
17. Structure, Regulation, and Function of TET Family Proteins
Xin Hu, Yun Chen and Zhizhuang Joe Zhao
18. Epigenetic drugs for cancer therapy
Bowen Yan, Xuehui Li, Yurong Yang, Wei Jian and Yi Qiu
19. Epigenetic Mechanisms as Key Regulators in Disease. Clinical Implications and Case Studies
Abdelhalim Boukaba, Fabian Sanchis-Gomar, José Luis García-Giménez
