Inhibitors of the Ras Superfamily G-proteins, Part B (The Enzymes)

Tamanoi, Fuyuhiko (EDT)/ Der, Channing J. (EDT)

Academic Press Inc（2013/12発売）

• 製本 Hardcover:ハードカバー版／ページ数 280 p.
• 言語 ENG
• 商品コード 9780124201460
• DDC分類 572.8

Full Description

Targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, this is the second part of The Enzymes' volumes that discuss inhibitors of the Ras superfamily G-proteins.

Contents

Discovery of Small-Molecule Ras Inhibitors that Display Anti-Tumor Activity by Interfering with Ras•GTP-Effector InteractionFumi Shima, Yoko Yoshikawa, Shigeyuki Matsumoto and Tohru Kataoka
An Orthosteric Inhibitor of the RAS-SOS InteractionSeth Nickerson, Stephen T. Joy, Paramjit S. Arora and Dafna Bar-Sagi
Conformation-Specific Inhibitors of Raf kinasesXiaolun Wang and Kristin Schleicher
Inhibitors of the ERK Mitogen-activated Protein Kinase Cascade for Targeting RAS Mutant CancersLeanna Gentry, Ahmed A. Samatar and Channing J. Der
Inhibiting the RAS - PI3K Pathway in Cancer TherapyClare Sheridan and Julian Downward
The RalGEF/Ral Pathway: Evaluating an Intervention Opportunity for Ras CancersJonathan M. Cooper, Brian O. Bodemann and Michael A. White
p21-Activated Kinase InhibitorsJoachim Rudolph, James J. Crawford, Klaus P. Hoeflich, and Jonathan Chernoff
Recent Progress in Developing Small Molecule Inhibitors Designed to Interfere with Ras Membrane Association: Towards Inhibiting K-Ras and N-Ras Functions Fuyuhiko Tamanoi and Jie Lu
Synthetic Lethal Genetic Screens in Ras Mutant CancersBing Yu and Ji Luo