Inhibitors of the Ras Superfamily G-proteins, Part a (The Enzymes)

Tamanoi, Fuyuhiko (EDT)

Academic Press Inc（2013/09発売）

• 製本 Hardcover:ハードカバー版／ページ数 364 p.
• 言語 ENG
• 商品コード 9780124167490
• DDC分類 572.6

Full Description

This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins.

Contents

The Ras superfamily G-proteins
Fuyuhiko Tamanoi
NMR Study to Identify a Ligand-Binding Pocket in Ras
Till Maurer and Weiru Wang
The Allosteric Switch and Conformational States in Ras GTPase Affected by Small Molecules
Christian W. Johnson and Carla Mattos
State 1(T) Inhibitors of Activated Ras
Hans Robert Kalbitzer and Michael Spoerner
Sugar-Based Inhibitors of Ras Activation: Biological Activity and Identification of Ras-Inhibitor Binding Interface 
Alessandro Di Domizio and Francesco Peri
Development of EHop-016, a Small Molecule Inhibitor of Rac
Suranganie Dharmawardhane
Aptamer-Derived Peptide Inhibitors of Rho Guanine Nucleotide Exchange Factors
Susanne Schmidt and Anne Debant
Targeting the Dbl and Dock-Family RhoGEFs: a Yeast-Based Assay to Identify Cell-Active Inhibitors of Rho-Controlled Pathways
Anne Blangy and Philippe Fort
Inhibitors of the ROCK Serine/Threonine Kinases: Key Effectors of the RhoA Small GTPase
Dominico Vigil and Channing J. Der
A Two-Hybrid Approach to Identify Inhibitors of the RAS-RAF Interaction
Vladimir Khazak, Susanne Eyrisch, Juran Kato, Fuyuhiko Tamanoi and Erica A. Golemis
Inhibitors of K-Ras Plasma Membrane Localization
Kwang-jin Cho, Dharini van der Hoeven and John F. Hancock
Ras Chaperons: New Targets for Cancer and Immunotherapy
Yoel Kloog, Galit Elad-Sfadia, Roni Haklai and Adam Mor