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基本説明
Detailed and multidisciplinary discussion of the physical, chemical, mechanical, surface and in vitro characterization tools and techniques used to effectively analyze biomaterials.
Full Description
One of the key challenges current biomaterials researchers face is identifying which of the dizzying number of highly specialized characterization tools can be gainfully applied to different materials and biomedical devices. Since this diverse marketplace of tools and techniques can be used for numerous applications, choosing the proper characterization tool is highly important, saving both time and resources. Characterization of Biomaterials is a detailed and multidisciplinary discussion of the physical, chemical, mechanical, surface, in vitro and in vivo characterization tools and techniques of increasing importance to fundamental biomaterials research.Characterization of Biomaterials will serve as a comprehensive resource for biomaterials researchers requiring detailed information on physical, chemical, mechanical, surface, and in vitro or in vivo characterization. The book is designed for materials scientists, bioengineers, biologists, clinicians and biomedical device researchers seeking input on planning on how to test their novel materials, structures or biomedical devices to a specific application. Chapters are developed considering the need for industrial researchers as well as academics.
Contents
Chapter 1. Introduction to Biomaterials Natural and synthetic biomaterials - an introductionApplications of biomaterialsA few case studies related to failures of biomaterials and its impact - focus on need for appropriate characterization of biomaterialsChapter 2: Physical and Chemical Characterization of BiomaterialsPhysical properties of biomaterials - an introductionMicrostructural characterization of biomaterialsPhase changes in biomaterials - this part will focus on understanding phase change behavior and their measurement techniques in various materials like NiTi type shape memory alloys for stents or calcium phosphate ceramics and their phase change as a function of temperature, pH and so on.Porous biomaterials - Different types of porosity and their impact on biomaterials.Structural characterization of biomaterials - focus will be on different techniques such as IR, NMR, and other spectroscopic analysis. Chapter 3. Mechanical Characterization of BiomaterialsMechanical properties of biomaterials - an introductionUniaxial deformation in biomaterialsMultiaxial such as biaxial and bending/flexural deformation in biomaterialsCyclic deformation in biomaterialsRotating bending fatigueTension-tension, tension-compression and compression-compression fatigueChapter 4. Surface Characterization of BiomaterialsSurface properties of biomaterials - an introductionSurface chemistry, surface roughness, wetting and surface energy Hardness measurements - macro, micro and nano-indentationsAdhesion and interfacial strengths of coatingsSurface degradation of biomaterialsChapter 5. In vitro Characterization of Biomaterials ICell-materials interactions on biomaterials - an introductionCytocompatibility assessmentMeasurements of cell adhesion, proliferation and differentiation of cell-materials interactionsImmunochemistry and protein assaysAnti-microbial characterization of materialsChapter 6. In vivo Characterization of Biomaterials IITissue materials interactions with biomaterials - an introductionBiocompatibility studiesTissue materials interactions - Histology and histomorphometric analysisBiodistribution studiesTissue integration and bio-mechanical analysisChapter 7. Characterization of Biomedical DevicesDevice level testing vs. materials analysis - an introductionCase studies - a few selected case studies will be presented towards device level characterization such as Wear behavior of articulating surfaces in biomaterials
