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Full Description
Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. This volume brings together different aspects of, and approaches to, molecular and multi-scale modeling, with applications to a diverse range of neurological diseases.
Mathematical and computational modeling offers a powerful approach for examining the interaction between molecular pathways and ionic channels in producing neuron electrical activity. It is well accepted that non-linear interactions among diverse ionic channels can produce unexpected neuron behavior and hinder a deep understanding of how ion channel mutations bring about abnormal behavior and disease. Interactions with the diverse signaling pathways activated by G protein coupled receptors or calcium influx adds an additional level of complexity. Modeling is an approach to integrate myriad data sources into a cohesive and quantitative model in order to evaluate hypotheses about neuron function. In particular, a validated model developed using in vitro data allows simulations of the response to in vivo like spatio-temporal patterns of synaptic input. Incorporating molecular signaling pathways into an electrical model, allows a greater range of models to be developed, ones that can predict the response to pharmaceuticals, many of which target neuromodulator pathways.
Contents
Markov Modeling of Ion Channels: Implications for Understanding DiseaseAngelika Lampert and Alon Korngreen
Ionic Mechanisms in Peripheral PainErik Fransen
Implications of Cellular Models of Dopamine Neurons for SchizophreniaNa Yu, Kristal R. Tucker, Edwin S. Levitan, Paul D. Shepard and Carmen C. Canavier
The Role of IP3 Receptor Channel Clustering in Ca2+ Wave Propagation during Oocyte MaturationAman Ullah, Peter Jung, Ghanim Ullah and Khaled Machaca
Modeling Mitochondrial Function and its Role in DiseaseM. Saleet Jafri and Rashmi Kumar
Mathematical Modeling of Neuronal Polarization During DevelopmentHonda Naoki and Shin Ishii
Multiscale Modeling of Cell Shape from the Actin CytoskeletonPadmini Rangamani, Granville Yuguang Xiong and Ravi Iyengar
Computational Modeling of Diffusion in the CerebellumToma M. Marinov and Fidel Santamaria
Astrocyte-Neuron Interactions: From Experimental Research Based Models to Translational MedicineMarja-Leena Linne and Tuula O. Jalonen
Dynamic Metabolic Control of an Ion ChannelBertil Hille, Eamonn Dickson, Martin Kruse and Bjoern Falkenburger
Modeling Molecular Pathways of Neuronal IschemiaZachary H. Taxin, Samuel A. Neymotin, Ashutosh Mohan, Peter Lipton and William W. Lytton
Modeling Intracellular Signaling Underlying Striatal Function in Health and DiseaseAnu G. Nair, Omar Gutierrez-Arenas, Olivia Eriksson, Alexandra Jauhiainen, Kim T. Blackwell and Jeanette Hellgren Kotaleski
Data-Driven Modelling of Synaptic Transmission and IntegrationJason S. Rothman and R. Angus Silver
Multi-Scale Modeling and Synaptic PlasticityUpinder S. Bhalla
