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Full Description
This special volume of Progress in Molecular Biology and Translational Science focuses on the molecular biology of arrestins, with contributions from leaders in the field. Arrestins have emerged as central players in the regulation of many facets of G protein-coupled receptor signaling. This volume covers a variety of topics with reviews written by experts in the field.
Contents
Part I: Perspective - The Duality of Arrestin Function
1. Arrestins Come of Age: A Personal Historical Perspective
Part II: The Molecular Biology of Arrestins
2. True Arrestins and Arrestin-Fold Proteins: A Structure-Based Appraisal
3. Structural Determinants of Arrestin Functions
4. Arrestins: Role in the Desensitization, Sequestration and Vesicular Trafficking of G Protein-Coupled Receptors
5. Arrestins as Regulators of Kinases and Phosphatases
6. ß-Arrestins: Modulators of Small GTPase Activation and Function
7. Arrestins and Protein Ubiquitination
8. Arrestins in Actin Reorganization and Cell Migration
Part III: The Physiological Roles of Arrestins
9. The Role of Arrestins in Development
10. The Role of Arrestins in Visual and Disease Processes of the Eye
11. b-Arrestins in the Central Nervous System
12. Arrestins in the Cardiovascular System
13. Arrestins in Bone
14. b-Arrestins in the Immune System
15. The Role of b-Arrestins in Cancer
16. Arrestins in Metabolic Regulation
Part IV: The Future - The Potential for Arrestin-based Therapeutics
17. Systems Analysis of Arrestin Pathway Functions
18. Arrestin Pathways as Drug Targets
