Full Description
DNA methylation is essential for the normal development and functioning of organisms. This volume discusses the latest developments in this very active field of research. It presents the evolution of DNA methylation, mammalian DNA methyltransferases, DNA methylation and demethlyation, DNA methylation and silencing and the role it plays in medicine including cancer.
Contents
1. Introduction - Epiphanies in Epigenetics
Xiaodong Cheng and Robert M. Blumenthal
Section I. EVOLUTION OF DNA METHYLATION
2. The natural history of eukaryotic DNA methylation systems
Lakshminarayan M. Iyer, Saraswathi Abhiman, L. Aravind
3. Evolution of histone methyltransferases and demethylases
L. Aravind
4. DNA methylation in Drosophila - A critical evaluation
Veiko Krauss and Gunter Reuter
5. DNA Methylation in Zebrafish
Mary G Goll and Marnie E Halpern
Seciton II. MAMMALIAN DNA METHYLTRANSFERASES - STRUCTURE AND FUNCTION
6. Dnmt1 - structure and function
Željko M. Svedružić
7. The DNMT3 family of MAMMALIAN de novo DNA methyltransferases
Frédéric Chédin
Seciton III. DNA METHYLATION AND DEMETHYLATION
8. Recruitment of Dnmt1: Roles of the SRA protein Np95 (Uhrf1) and other factors
Jafar Sharif & Haruhiko Koseki
9. Regulation of Expression and Activity of DNA (cytosine-5) methyltransferases in mammalian cells
Shannon R. Morey Kinney and Sriharsa Pradhan
10. Mechanistic and functional links between histone methylation and DNA methylation
Taiping Chen
Section IV. DNA METHYLATION IN MEDICINE
11. RNA mediated silencing mechanisms in mammalian cells
Anton Wutz
12. Biological functions of methyl-CpG binding proteins
Pierre-Antoine Defossez and Irina Stancheva
Section V. DNA METHYLATION IN MEDICINE
13. Diseases associated with imprinting
J.F. Wilkins and F. Úbeda
14. DNA methylation changes in cancer
Minoru Toyota and Eiichiro Yamamoto
15. Epigenetic biomarkers
J. Tost
16. Distribution of methylation at the single-nucleotide level
E.
