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基本説明
Contributions from technology and research leaders provide an interdisciplinary perspective of systems biology approaches, current applications and future prospects to help achieve translational results.
Full Description
This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics.
Contents
SECTION I: Component of biological systems
1. Proteomic analysis of cellular systems
2. The protein-coding transcriptome
3. ncRNAs and their targets
SECTION II: Network properties of biological systems
4. Probabilistic functional networks
5. Protein-protein inteactome networks
6. Gene regulatory networks
7. Phenotypic profiling networks
8. Genetic interaction networks
9. Chromatin networks
10. Drug-target networks
11. Graph theory properties of cellular networks
SECTION III: Dynamic and logical propoerties of biological systems
12. Boolean models of cellular networks
13. Bayesian approaches in understanding networks
14. Transcriptional network logic in development
15. Metabolic systems reconstruction
16. Evolution of biological networks
17. Systems understanding of the cell cycle
18. Quantitative design principles on molecular systems
19. Systems biology of signaling
20. Single cell systems dynamics
21. Spatial organization of cellular systems
SECTION IV: Systems and biology
22. Systems understanding of yeast biology
23. Systems understandingof c.elegans development
24. Biological systems in Arabidopsis
25. Biological rhythms in development and hemeostasis
26. System biology of stem cells
27. The brain connectome
SECTION V: MULTISCALE BIOLOGICAL SYSTEMS, HEALTH AND ECOLOGY
28. Systems medicine
29. Cancer systems biology
30. Infectious disease and the immune system
31. Network perturbations and disease states
32. Impact of personal genomics on systems biology
33. Social networks, human disease, and epidemics
