Full Description
This monograph was assembled to honor Professor Norman Bowery and his work on the 30th anniversary of his discovery of the GABAB receptor. In the present volume, leading neuroscientists from academia and industry provide a perspective of current research, both basic and translational, in the discovery of drugs acting at the GABAB receptor. The topics covered provide a comprehensive review of the field and the current state of research in this area. Included are chapters on the chemistry of GABAB agonists and antagonists, on the genetics and molecular composition of the site, its regulation and trafficking, and its role in controlling cellular, autonomic, and behavioral function. There are also chapters describing the potential clinical utility of drugs regulating GABAB activity receptor in the areas of hypertension, gastroesophageal reflux disease, Down syndrome, depression, and substance abuse.
The information contained in this text will be of particular interest to neuroscientists in general and to neuropharmacologists in particular.
Contents
1. Historical Perspective and Emergence of the GABAB Receptor
Norman Bowery
2. Chemistry of GABAB Receptor Ligands
Wolfgang Froestl
3. Heterodimerization of the GABAB Receptor - Implications for GPCR Signaling and Drug Discovery
Fiona H. Marshall and Steven M. Foord
4. Mechanisms of GABAB Receptor Exocytosis, Endocytosis and Degradation
Deitmar Benke
5. Functional Modulation of GABAB Receptors by Protein Kinases and Receptor Trafficking
Miho Terunuma, Andres Couve, Menelas N. Pangalos, and Stephen J. Moss
6. GABAB Receptor Coupling to G Proteins and Ion Channels
Claire Padgett and Paul A. Slesinger
7. GABAB Receptor-mediated Modulation of Metabotropic Glutamate Signaling and Synaptic Plasticity in Central Neurons
M. Kano and Toshihide Tabata
8. GABA Transporter GAT1: A Crucial Determinant of GABAB Receptor Activation in Cortical Circuits?
Guillermo Gonzalez-Burgos
9. The Role of GABAB Receptors in Cortical Network Activity
Michael M. Kohl and Ole Paulsen
10. GABAB Receptors: Physiology Functions and Mechanisms of Diversity
Andree Pinard, Riad Seddik, and Bernhard Bettler
11. Role of GABAB Receptors in Autonomic Control of Systemic Blood Pressure
De-Pei Li and Hui-Lin Pan
12. GABAB Receptor Agonism as a Novel Therapeutic Modality in the Treatment of Gastroesophageal Reflux Disease
Anders Lehmann, Jorgen Jensen, and Guy E. Boeckxstaens
13. GABAB Receptors in Reward Processes
Styliani Vlachou and Athina Markou
14. GABAB Receptors in Addiction and Its Treatment
David J. Nutt, Anne Lingford-Hughes, Laurence John Reed, and Robin J. Tyacke
15. GABAB - GIRK2 Mediated Signaling in Down Syndrome
Nathan Cramer, Tyler Best, and Zygmunt Galdzicki
16. GABAB Receptors and Depression: Current Status
John F. Cryan and David A. Slattery
17. GABAB Receptors in Drosophila
Hari Manev and Svetlana Dzitoyeva
