Full Description
Since the publication of the first edition, the U.S. Surgeon General released the first-ever report on bone health and osteoporosis in October 2004. This report focuses even more attention on the devastating impact osteoporosis has on millions of lives. According to the National Osteoporosis Foundation, 2 million American men have osteoporosis, and another 12 million are at risk for this disease. Yet despite the large number of men affected, the lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated. It is estimated that one-fifth to one-third of all hip fractures occur in men.
This second edition brings on board John Bilezikian and Dirk Vanderschueren as editors with Eric Orwoll. The table of contents is more than doubling with 58 planned chapters. The format is larger - 8.5 x 11. This edition of Osteoporosis in Men brings together even more eminent investigators and clinicians to interpret developments in this growing field, and describe state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy.
Contents
Section 1 Essentials of bone biology
1. The Biochemistry of Bone: Composition and Organization
2. Bone Remodeling: Cellular Activities in Bone
3. Assessment of Bone Turnover Using Biochemical Markers
4. Fundamentals of Mineral Homeostasis
5. The Mechanical Properties of Bone
6. Assessment of Bone Architecture
Section 2 Development and growth of the male skeleton
7. Skeletal Growth in Males
8. Pubertal Growth of the Male Skeleton
9. The Effects of Sex Steroids on Bone Growth
10. Nutritional Basis of Skeletal Growth
11. Physical Activity and Skeletal Growth
Section 3 Skeletal genetics
12. The Genetics of Peak Bone Mass
Section 4 Aging and the male skeleton
13. Age-Related Changes in Bone Remodeling and Micro Architecture
14. Markers of Bone Remodeling and the Aging Skeleton
15. Alterations in Mineral Metabolism in the Aging Male
16. Change in Bone Size and Geometry with Aging
17. Aging and Bone Density
18. The Effect of Age on Material Properties
Section 5 Nutritional issues
19. Calcium, Bone Strength and Fractures
20. Vitamin D and Bone
21. Role of Dietary Protein in Bone Growth and Bone Loss
Section 6 Sex steroids and the skeleton in men
22. The Molecular Biology of Sex Steroids in Bone: Similarities and Differences Among the Sexes
23. Estrogen and the Skeleton - Rodents
24. Estrogen and the Skeleton - Humans
25. Androgens and the Skeleton - Animal Models
26. Androgens and the Skeleton - Humans
27. Androgen Effects on the Skeletal Muscle
Section 7 Fractures in men
28. Epidemiology of Fractures
29. Individualized Progress of Fractures in Men
30. Physical Activity, Physical Function and Fall and Fracture Risk in Older Men
31. Economic Impact of Osteoporotic Fractures (vs women)
32. Adverse Health Outcomes in Men with Osteoporosis
Section 8. Metabolic bone disease in men
33. Idiopathic Osteoporosis
34. Glucocorticoid Induced Osteoporosis
35. Testicular Dysfunction
36. Alcohol and Bone
37. Transplantation Osteoporosis
38. Management of Fractures in Men with Impaired Renal Function
39. Hyperparathyroidism
40. Hypercalciuria
41. The Skeletal Phenotype of the Male Athlete
42. Inherited and Related Disorders of Bone Matrix Synthesis in Men
Section 9 Diagnostic approach
43. Dual-Energy X-ray Absorptiometry (DXA) in Men
44. Quantitative Ultrasound Diagnosis of Osteoporosis in Men
45. Advanced Structural Assessment of Bone Using CT and MRI
46. Vertebral Fracture Assessments
47. The Use of Bone Biopsies in the Diagnosis of Male Osteoporosis
48. Overall diagnostic strategy
Section 10 Therapy
49. Diagnostic Thresholds for Osteoporosis in Men
50. Cost-Effectiveness of Interventions to Reduce Osteoporosis-Related Fractures in Men: Current Data, Controversies, and Challenges
51. Nutritional Therapy for Skeletal Health in Men
52. Exercise Programs for Patients with Osteoporosis
53. Calcitonin: History, Physiology, Pathophysiology and Therapeutic Applications
54. Treatment of Male Osteoporosis with Bisphosphonates
55. Treatment of Male Osteoporosis with Parathyroid Hormone
56. Testosterone Therapy for Osteoporosis in Men
57. Future Therapies: Strontium, SERMs, SARMs and New Therapies on the Horizon
