基本説明
Designed as the most authoritative and modern resource for the
broad range of investigators in various medical specialties taking on the
challenge of clinical research.
Full Description
Clinical or translational science is the field of study devoted to investigating human health and disease, interventions and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead to a better understanding of human disease and the application of new therapeutics for enhanced health.Clinical and Translational Science is designed as the most authoritative and modern resource for the broad range of investigators in various medical specialties taking on the challenge of clinical research. Prepared with an international perspective, this resource begins with experimental design and investigative tools to set the scene for readers. It then moves on to human genetics and pharmacology with a focus on statistics, epidemiology, genomic information, drug discovery and development, and clinical trials. Finally, it turns to legal, social, and ethical issues of clinical research concluding with a discussion of future prospects to provide readers with a comprehensive view of the this developing area of science.
Contents
List of ContributorsForewordAcknowledgmentsIntroduction to Clinical ResearchPart I Fundamental Principles1 Patient-Oriented Research: Clinical Pathophysiology and Clinical Therapeutics2 Clinical TrialsPart II Approaches3 Experimental Design4 Introduction to Biostatistics Ideas5 Measurement of Biological Materials6 Imaging Tools in Human Research7 Imaging Tools in Cardiovascular Research8 Nanotechnology in Clinical and Translational Research9 The Use of Questionnaires and Surveys10 Information TechnologyPart III Infrastructure11 Clinical and Translational Science Infrastructure12 Industry-Sponsored Clinical Research in AcademiaPart IV Education, Training and Career Choices13 Training Basic, Clinical and Translational Investigators14 A Stepwise Approach to a Career in Translational Research15 Physician Careers in IndustryPart V Funding16 Governmental Support of Research17 Support of Health Research by Private Philanthropy18 Pharmaceutical and Biotechnology Sector Support of ResearchPart VI Human Genetics19 Introduction to Human Genetics20 Epidemiologic and Population Genetic Studies21 Pharmacogenetics of Drug MetabolismPart VII Human Pharmacology22 Introduction to Clinical Pharmacology23 Toxicology and Genetics of Adverse Drug Events24 Good Clinical Practice and Good Laboratory Practice25 Modern Drug Discovery and DevelopmentPart VIII Societal Context of Human Research26 Translating Science to the Bedside: The Innovation Pipeline27 Regulatory Environment28 Ethical Issues in Translational Research and Clinical Investigation29 Clinical Research in the Public EyePart IX Research in Special Populations30 Acute Illnesses, Critical Care, Emergency and Surgical Patients31 Psychiatric Disorders32 Geriatrics33 PediatricsPart X Population-Based Research34 Pharmacoeconomics: The Economic Evaluation of New Medical Technology35 Introduction to Epidemiology36 Health Services Research: Translating Discovery and Research into Practice and PolicyPart XI Prospectus37 The Future of Clinical ResearchIndex
