Full Description
The immunoglobin gene complex is responsible for generating an extraordinary wide range of antbodies, each possessing a unique antigen specificity. The Second Edition of Immunogobulin Genes brings the reader up-to-date with the rapid progress in our understanding of this system. Firmly established as the definitive book on the topic, it provides a fully comprehensive account of the organization, function, rearrangement, and expression of these and related genes. Since the publication of the First Edition, the work has been extensively revised and updated to cover new research data on human immunoglobulin genes as well as mammmalian and lower vertebrate systems. New chapters include "Somatic Mutation and B-Cell Maturation," "Antigen Receptors," and "B Lymphocyte Tolerance in the Mouse."
Features: * Conveys the excitement of research on immunoglobulin genes by the range and complexity of issues * Contains invaluable information for clinicians and research scientists with an interest in the immune response * For the Immunologist * Detailed descriptions of the molecular mechanisms generating this diverse range of antibodies and the regulation of genes encoding them * For the Molecular Biologist * Discusses important phenomena including gene rearrangement, differential splicing, and deletion in the context of immunoglobulin genes.
Contents
Part 1 B cells: human b-cell differentiation, M. Cooper; murine b-cell differentiation, F. Melchers; somatic mutation and b-cell maturation, C. Milstein; development of b-cell subsets, L. Herzenberg; regulation of b-cell stroma cells, O. Witte; antigen receptors, M. Reth. Part 2 Organization and rearrangement of immunoglobulin genes: immunoglobin heavy chain loci in mouse and men, H. Honjo and F. Matsuda; the human immunoglobulin genes, H. Zachau; organization of lambda chain genes, E. Selsing; VDJ recombination, F. Alt; regulation of class switch recombination of the immunoglobulin heavy chain genes, F.W. Alt and T. Honjo; organization and expression of chicken and sheep Ig genes, J.C. Weill; immunoglobulin heavy chain genes of rabbit, K. Knight; the structure and organization of immunoglobulin genes in lower vertebrates, G. Litman. Part 3 Immunoglobulin gene expression: ig gene expression and regulation in Ig transgenic mice, U. Storb; b-lymphocyte tolerance in the mouse, D. Nemazee; auto antibodies, D. Capra; regulation of Ig H and L chain gene transcription, S. Ghosh.
