Full Description
Wound repair is an important and growing sector of the medical industry with increasingly sophisticated biomaterials and strategies being developed to treat wounds. Advanced wound repair therapies provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds.Part one provides an introduction to chronic wounds, with chapters covering dysfunctional wound healing, scarring and scarless wound healing and monitoring of wounds. Part two covers biomaterial therapies for chronic wounds, including chapters on functional requirements of wound repair biomaterials, polymeric materials for wound dressings and interfacial phenomena in wound healing. In part three, molecular therapies for chronic wounds are discussed, with chapters on topics such as drug delivery, molecular and gene therapies and antimicrobial dressings. Part four focuses on biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair. Finally, part five covers physical stimulation therapies for chronic wounds, including electrical stimulation, negative pressure therapy and mechanical debriding devices.With its distinguished editor and international team of contributors, Advanced wound repair therapies is an essential reference for researchers and materials scientists in the wound repair industry, as well as clinicians and those with an academic research interest in the subject.
Contents
Contributor contact detailsIntroductionPart I: Introduction to chronic woundsChapter 1: Dysfunctional wound healing in chronic woundsAbstract:1.1 Normal skin wound healing1.2 Ageing skin and the onset of chronic, dysfunctional wound healing1.3 Dysfunctional healing of chronic skin wounds1.4 Conclusions1.5 AcknowledgementsChapter 2: The role of micro-organisms and biofilms in dysfunctional wound healingAbstract:2.1 Introduction2.2 Microbiology and biofilms: not mutually exclusive2.3 Biofilms and the interactive cooperative community2.4 Biofilms in chronic wounds2.5 Biofilms as therapeutic or restorative microbiology/modeling2.6 ConclusionChapter 3: Scarring and scarless wound healingAbstract:3.1 Introduction3.2 Wound healing process3.3 Fibroproliferative scarring3.4 Scarless fetal wound healing3.5 Adult versus fetal wound healing3.6 Treatment options for scars3.7 Future trends3.8 ConclusionsChapter 4: The discovery and development of new therapeutic treatments for the improvement of scarringAbstract:4.1 Introduction4.2 Scar-free and scar-forming healing4.3 In vitro and in vivo models to investigate the mechanisms of scarring and evaluate potential treatments4.4 Translation from pre-clinical studies to clinical efficacy4.5 Understanding the mechanisms of action of prophylactic scar improvement therapies4.6 ConclusionsChapter 5: Monitoring chronic wounds and determining treatmentAbstract:5.1 Introduction5.2 Wound size measurements5.3 Wound colour measurements5.4 Background materialPart II: Biomaterial therapies for chronic woundsChapter 6: Functional requirements of wound repair biomaterialsAbstract:6.1 Introduction6.2 Wound pain and dressing materials6.3 Exudate management6.4 Prevention and control of infection6.5 Odour management6.6 Future trends6.7 Sources of further information and adviceChapter 7: Tissue-biomaterial interactionsAbstract:7.1 Introduction: definitions7.2 Overview of tissue-biomaterial interactions7.3 Interactions at the biomaterial surface7.4 Tissue response to biomaterial7.5 ConclusionChapter 8: Polymeric materials for chronic wound and burn dressingsAbstract:8.1 Introduction8.2 Advanced moisture-retentive wound dressings8.3 Polymeric materials in moist wound healing dressings8.4 Infection control by polymeric wound dressings8.5 Conclusion8.6 Future trends8.7 AcknowledgementsChapter 9: Dry wound healing concept using spray-on dressings for chronic woundsAbstract:9.1 Introduction9.2 The key properties of an ideal wound dressing9.3 Using protein-based spray-on dressings in practice9.4 Case studies9.5 ConclusionsChapter 10: Assessing the effectiveness of antimicrobial wound dressings in vitroAbstract:10.1 Introduction10.2 Log reduction testing10.3 Zone of inhibition (ZOI)10.4 Bacterial barrier testing10.5 Other considerations10.6 Sources of further information and adviceChapter 11: Adhesives and interfacial phenomena in wound healingAbstract:11.1 Principles of adhesion, adhesivity and interfacial behaviour11.2 Bioadhesion: principles of adhesion applied to wound healing11.3 Adhesives in wound healing: materials overview11.4 Surgical adhesives and tissue sealants: structure and properties11.5 ConclusionsChapter 12: Wound healing studies and interfacial phenomena: use and relevance of the corneal modelAbstract:12.1 Wound dressing biomaterials: interfacial aspects of compatibility and wound response12.2 The corneal model in wound healing and biomaterial studies12.3 Interfacial phenomena in ocular surface contact lens studies12.4 Wound fluid and the tear film collection12.5 Biomaterials in mucosal wound healing12.6 ConclusionsChapter 13: Sulphonated biomaterials as glycosaminoglycan mimics in wound healingAbstract:13.1 Introduction13.2 Polymers and biomimesis13.3 Biomimetic models13.4 Sulphonated biomaterials in the context of biomimetic principles13.5 Sulphonated biomaterials and the chronic wound: possible modes of biomimetic behaviour13.6 ConclusionsPart III: Molecular therapies for chronic woundsChapter 14: Drug delivery dressingsAbstract:14.1 Introduction14.2 The role of drug delivery dressings in wound management14.3 Topically delivered therapeutic compounds14.4 Hydrocolloids14.5 Hydrogels14.6 Collagen14.7 Alginates14.8 Honey14.9 Future trendsChapter 15: Molecular and gene therapies for wound repairAbstract:15.1 Introduction15.2 Methods of gene delivery15.3 Gene therapy for wound healing15.4 Ethical issues15.5 Future trendsChapter 16: Antimicrobial dressingsAbstract:16.1 Introduction16.2 Types of currently available dressings/formulations16.3 Types of 'antimicrobials'16.4 Future trendsChapter 17: Avotermin: emerging evidence of efficacy for the improvement of scarringAbstract:17.1 There is a medical need for therapies that reduce scarring following surgery17.2 Current treatments for scar management are unsatisfactory17.3 New biological approaches are in development for the prophylactic improvement of scarring17.4 Conclusions and future trendsPart IV: Biologically derived and cell-based therapies for chronic woundsChapter 18: Engineered tissues for wound repairAbstract:18.1 Introduction18.2 The wound microenvironment in wound repair18.3 Traditional approaches to wound repair18.4 Development of cellular therapies18.5 Development of acellular therapies18.6 Conclusion18.7 AcknowledgementChapter 19: Commercialization of engineered tissue productsAbstract:19.1 Introduction19.2 Engineered templates and scaffolds19.3 Processed tissues19.4 Cell-based products19.5 Lessons from the first generation19.6 The second generation of advanced therapies19.7 Delivering value in advanced therapies19.8 Advanced therapies in the marketplace19.9 ConclusionChapter 20: Biologically derived scaffoldsAbstract:20.1 Introduction20.2 Polyhydroxyalkanoate (PHA)-derived scaffolds20.3 Silk-derived scaffolds20.4 Collagen-derived scaffolds20.5 Elastin-derived scaffolds20.6 Resilin-derived scaffolds20.7 Keratin-derived scaffolds20.8 Polysaccharide-derived scaffolds20.9 Conclusions and future trendsChapter 21: Stem cell therapies for wound repairAbstract:21.1 Introduction21.2 Frequently utilized sources of adult stem cells21.3 Clinical applications of stem cells to wound healing21.4 Conclusions21.5 Acknowledgement21.7 Appendix: list of abbreviationsPart V: Physical stimulation therapies for chronic woundsChapter 22: Electrical stimulation for wound healingAbstract:22.1 Introduction22.2 Current of injury22.3 Physiological effects of electrical stimulation22.4 Antibacterial effects of electrical stimulation22.5 The effect of high voltage pulsed current (HVPC) on wound healing22.6 The effect of low intensity direct currents (LIDC) on wound healing22.7 Other types of electrical stimulation applied to wounds22.8 Discussion22.9 ConclusionChapter 23: Negative pressure wound therapyAbstract:23.1 Introduction23.2 History of negative pressure wound therapy23.3 The science of negative pressure23.4 The pathophysiologic mechanisms of action of negative pressure23.5 The search for the perfect negative pressure technology23.6 Conclusions23.7 AcknowledgementChapter 24: Debridement methods of non-viable tissue in woundsAbstract:24.1 Introduction24.2 Background24.3 Complications of non-viable tissue in wounds and the need for debridement24.4 Presence of biofilm24.5 Organisation of debridement24.6 Timing and types of debridement24.7 Scoring the effectiveness of debridement24.8 Debridement in the diabetic foot24.9 ConclusionsIndex
