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Full Description
Given their direct impact on the health and quality of life for millions, inhalers represent a major turning point in the history of modern medicine. Inhaler devices: Fundamentals, design and drug delivery provides readers with an introduction to the fundamentals of inhaler technology, with a comprehensive discussion of the history of inhalers as well as a discussion on current research and development.Part one discusses the fundamentals and development of inhaler devices as well as drug formulations for inhalers. The treatment of asthma is also discussed. Part two reviews recent developments in drug formulation and nanotechnology for inhaler devices, emerging inhaler technology and possible future trends.Inhaler devices: Fundamentals, design and drug delivery is an essential design guide for good industrial practice, and will be an invaluable resource for those researching and treating conditions such as asthma; and those developing and manufacturing inhalation devices.
Contents
Contributor contact detailsWoodhead Publishing Series in BiomaterialsPrefacePart I: Fundamentals and considerations of inhaler devicesChapter 1: Anatomy and pathophysiology of the respiratory systemAbstract:1.1 Introduction1.2 Functional anatomy1.3 Pathophysiology1.4 Analysis of pathophysiologyChapter 2: History of inhaler devicesAbstract:2.1 Introduction2.2 Structure and function of the lungs2.3 Inhalers and successful therapy2.4 Nebulisers2.5 Pressurised metered-dose inhalers (pMDIs)2.6 Dry powder inhalers2.7 Future trendsChapter 3: Tribology of inhaler devices and componentsAbstract:3.1 Introduction3.2 Design and principles of pressurised metereddose inhalers (pMDIs)3.3 Friction and lubrication within inhaler devices3.4 Measuring friction between pMDI componentsChapter 4: Novel coatings and biotechnology trends in inhaler devicesAbstract:4.1 Introduction4.2 Current trends in inhaler devices4.3 Novel coatings4.4 BiotechnologyChapter 5: Microbial control and safety in inhalation devicesAbstract:5.1 Microbial cells5.2 Growth of microorganisms in the environment5.3 Microbial inactivation5.4 Microbial contamination control5.5 Keeping inhalers microbiologically safePart II: Drug formulations for inhaler devicesChapter 6: Chitosan and inhalers: a bioadhesive polymer for pulmonary drug deliveryAbstract:6.1 Introduction6.2 Chitosan-based inhaler drug delivery systems6.3 The absorption enhancing effect of chitosan6.4 Types of particle systems used in inhalers6.5 Inhaler formulations based on chitosan and chitosan derivatives6.6 ConclusionsChapter 7: Polyelectrolyte assemblies for drug storage and delivery: multilayers, nanocapsules and multicapsulesAbstract:7.1 Introduction7.2 Layer-by-layer (LbL) multilayers for drug delivery applications: planar polyelectrolyte multilayers and capsules7.3 Assembling of layer-by-layer multilayers7.4 Variables affecting the electrostatic self-assembling7.5 Properties of polyelectrolyte multilayers of interest in drug delivery7.6 Encapsulation approximations7.7 Encapsulating bioactive molecules7.8 Strategies for releasing encapsulated drugs7.9 Layer-by-layer capsules in drug delivery applications7.10 Layer-by-layer capsules and inhalers7.11 Conclusions7.12 AcknowledgementsChapter 8: Functionalized core-shell nanoparticles for medical applicationsAbstract:8.1 Introduction8.2 New insights into copolymer-NSAID interactions8.3 Materials and methods of interfacial and bulk studies of copolymer-drug aqueous systems8.4 Experimental results and implications for intake and release mechanisms8.5 Conclusions8.6 AcknowledgementsIndex
