基本説明
In its 1990 recommendations, the ICRP considered the radiation risks after radiation exposures during prenatal development. This report critically reviews new experimental animal data on biological effects and evaluations of human studies after prenatal radiation published since then.
Thus, the report discusses radiation effects after exposure during preimplantation and developmental effects after irradiation during organogenesis and fetogenesis. The etiology of long-term effects during brain developments is discussed, as well as evidence from studies in man on the effects of in utero radiation exposure on neurological and mental processes. Assessments through animal studies of carcinogenic risk from in utero radiation are treated, and the epidemiology of childhood cancer is discussed; from this information the carcinogenic risk to man from in utero radiation is assessed. Open questions and needs for future research are elaborated.
The report reiterates that the mammalian embryo and fetus are very radiosensitive during prenatal development. The nature and sensitivity of induced biological effects depend upon dose and developmental stage at irradiation. The various effects, as studied in experimental systems and in man, are discussed in detail. It is concluded that the findings in the report strengthen and supplement the recommendations of the ICRP.
Full Description
In its 1990 recommendations, the ICRP considered the radiation risks after exposure during prenatal development. This report is a critical review of new experimental animal data on biological effects and evaluations of human studies after prenatal radiation published since the 1990 recommendations. Thus, the report discusses the effects after radiation exposure during pre-implantation, organogenesis, and fetogenesis. The aetiology of long-term effects on brain development is discussed, as well as evidence from studies in man on the effects of in-utero radiation exposure on neurological and mental processes. Animal studies of carcinogenic risk from in-utero radiation and the epidemiology of childhood cancer are discussed, and the carcinogenic risk to man from in-utero radiation is assessed. Open questions and needs for future research are elaborated. The report reiterates that the mammalian embryo and fetus are highly radiosensitive. The nature and sensitivity of induced biological effects depend upon dose and developmental stage at irradiation. The various effects, as studied in experimental systems and in man, are discussed in detail. It is concluded that the findings in the report strengthen and supplement the 1990 recommendations of the ICRP.
Contents
Preface Introduction 1. Radiation effects after exposure during the pre-implantation period 2. Developmental Effects after Irradiation during organogenesis and fetogenesis 3. Aetiology of long-term effects during brain development 4. Human evidence on the effects of in-utero radiation exposure on neurological and mental processes 5. Carcinogenic Risk from In-Utero Irradiation: Animal Studies 6. Epidemiology of Childhood Cancer 7. Human Carcinogenic Risk from In-Utero Irradiation 8. Summary and Conclusions 9. Open Questions and needs of future research
