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基本説明
第28版邦訳：2011・丸善出版（ISBN:9784621083284）。基礎から最新の知見までを収録した生化学教科書のバイブル、約３年毎に改訂。
Combining outstanding full-color illustrations with integrated coverage of biochemical diseases and clinical information, offers an organization and careful balance of detail and brevity not found in any other text on the subject. 28th ed.: 2009.
Full Description
This title helps you to gain a thorough understanding of the principles of biochemistry and molecular biology as they relate to modern medicine. It includes 16 case histories Clear, concise, and in full color, "Harper's Illustrated Biochemistry" is unrivaled in its ability to clarify the link between biochemistry and the molecular basis of disease. Combining outstanding full-color illustrations with integrated coverage of biochemical diseases and clinical information, Harper's offers an organization and careful balance of detail and brevity not found in any other text on the subject. Following two introductory chapters, the text is divided into six main sections: Section I addresses the structures and functions of proteins and enzymes. Section II explains how various cellular reactions utilize or release energy and traces the pathways by which carbohydrates and lipids are synthesized and degraded. Section III covers the amino acids, their metabolic fates, certain features of protein catabolism, and the biochemistry of the porphyrins and bile pigments. Section IV describes the structure and function of nucleotides and nucleic acids, DNA replication and repair, RNA synthesis and modification, protein synthesis, the principles of recombinant DNA technology, and new understanding of how gene expression is regulated. Section V deals with aspects of extracellular and intracellular communication. Section VI includes fifteen special topics, ranging from nutrition, digestion and absorption to the biochemistry of aging. New to this edition: it features New chapters on Aging, Cancer, and Clinical Chemistry; every chapter has been updated to reflect the latest advances in knowledge and technology; each chapter now begins with a statement of objectives, followed by a brief discussion of the biomedical importance of topics discussed within the chapter; it includes 250 multiple-choice questions to test your knowledge and comprehension; it provides increased number of tables that encapsulate important information, such as vitamin and mineral requirements.
Contents
Section 1: Structures and Functions of Proteins and Enzymes 1. Biochemistry & Medicine 2. Water & pH 7 3. Amino Acids & Peptides 4. Proteins:Determination of Primary Structure 5. Proteins: Higher Orders of Structure 6. Proteins: Myoglobin & hemoglobin 7. Enzymes:Mechanism of Action 8. Emzymes: Kinetics 9. Enzumes: regulation of Activities 10. Bioinformatics & Computational Biology Section 2: Bioenergetics and the Metabolism of Carbohydrates and Lipids 11. Bioenergetics: The Role of ATP 12. Biologic Oxidation 14. Carbohydrates of Physiologic Significance 15. Lipds of Physiologic Significance 16. Overview of Metabolism & the Provision of Metabolic Fuels 17. The Citric Acid Cycle: The Catabolism of Acetyl-CoA 18. Glycolysis & the Oxidation of Pyruvate 19. Metabolism of Glycogen 20. Gluconeogenesis & the Control of Blood Glucose 21. The Pentose Phosphate Pathway & Other Pathways of Hexose Metabolism 22. Oxidation of Fatty Acids: Ketogenesis 23. Biosynthesis of Fatty Acids & Eicosanoids 24. Metabolism of Acylglycerols & Sphingolipids 25. Lipid Transport & Storage 26. Cholesterol Synthesis, Transport, & Excretion Section 3: Metabolism of Proteins and Amino Acids 27. Biosynthesis of the Nutritionally Nonessential Amino Acids 28. Catabolism of Proteins & of Amino Acid Nitrogen 29. Catabolism of te Carbon Skeletons of Amino Acids 30. Conversion of Amino Acids to Speicalized Products 31. Pophyrins & Bile Pigments Section 4: Structure, Function and Replication of Infomraitonal Macromolecules 32. Nucleotides 33. Metabolism of Purine & Pyrimidine Nucleotides 34. Nucleic Acid Structure & Function 35. DNA Organization, Replication, & Repair 36. RNA Synthesis, Processing, & Modification 37. Protein Synthesis & The Genetic Code 38. Regulation of Gene Expression 39. Molecular Genetics, Recombinant DNA, & Genomic Technology Section 5: Biochemistry of Extracellular and Intracullular Communication 40. Membranes: Structure & Function 41. The diversity of the Endocrine System 42. Hormone Action & Signal Transduction Section 6: Special Topics (will highlight the 16 cases) 43. Nuturition, Digestion & Absorption 44. Micronutrients: Vitamins & Minerals 45. Free Radicals and Antioxidant Nutrients 46. Intracellular Traffic & Sorting of Proteins 47. Glycoproteins 48. The Extracellular Matrix 49. Muscle & the Cytoskeleton 50. Plasma Proteins & Immunoglobulins 51. Hemostasis & Thrombosis 52. Red & White Blood Cells 53. Metabolism of Xenobiotics 54. The Biochemistry of Aging 55. Cancer: An Overview 56. Clinical Biochemistry 57. Biochemical Case Histories Appendix The Answer Bank Index
