基本説明
第28版邦訳：2011・丸善出版（ISBN:9784621083284）。基礎から最新の知見までを収録した生化学教科書のバイブル、約３年毎に改訂。
Combining outstanding full-color illustrations with integrated coverage of biochemical diseases and clinical information, offers an organization and careful balance of detail and brevity not found in any other text on the subject. 28th ed.: 2009.
Full Description
Gain a thorough understanding of the principles of biochemistry and molecular biology as they relate to modern medicineIncludes 16 case historiesClear, concise, and in full color, Harper's Illustrated Biochemistry is unrivaled in its ability to clarify the link between biochemistry and the molecular basis of disease. Combining outstanding full-color illustrations with integrated coverage of biochemical diseases and clinical information, Harper's offers an organization and careful balance of detail and brevity not found in any other text on the subject.Following two introductory chapters, the text is divided into six main sections:Section I addresses the structures and functions of proteins and enzymes. Section II explains how various cellular reactions utilize or release energy and traces the pathways by which carbohydrates and lipids are synthesized and degraded. Section III covers the amino acids, their metabolic fates, certain features of protein catabolism, and the biochemistry of the porphyrins and bile pigments.Section IV describes the structure and function of nucleotides and nucleic acids, DNA replication and repair, RNA synthesis and modification, protein synthesis, the principles of recombinant DNA technology, and new understanding of how gene expression is regulated. Section V deals with aspects of extracellular and intracellular communication. Section VI includes fifteen special topics, ranging from nutrition, digestion and absorption to the biochemistry of agingNew to this edition:New chapters on Aging, Cancer, and Clinical ChemistryEvery chapter has been updated to reflect the latest advances in knowledge and technologyEach chapter now begins with a statement of objectives, followed by a brief discussion of the biomedical importance of topics discussed within the chapter250 multiple-choice questions to test your knowledge and comprehensionIncreased number of tables that encapsulate important information, such as vitamin and mineral requirements
Contents
Section 11. Biochemistry & Medicine2. Water & pH 73. Amino Acids & Peptides4. Proteins:Determination of Primary Structure5. Proteins: Higher Orders of Structure6. Proteins: Myoglobin & hemoglobin7. Enzymes:Mechanism of Action8. Emzymes: Kinetics9. Enzumes: regulation of Activities10. Bioinformatics & Computational BiologySection 2: Bioenergetics and the Metabolism of Carbohydrates and Lipids11. Bioenergetics: The Role of ATP12. Biologic Oxidation14. Carbohydrates of Physiologic Significance15. Lipds of Physiologic Significance16. Overview of Metabolism & the Provision of Metabolic Fuels17. The Citric Acid Cycle: The Catabolism of Acetyl-CoA18. Glycolysis & the Oxidation of Pyruvate19. Metabolism of Glycogen20. Gluconeogenesis & the Control of Blood Glucose21. The Pentose Phosphate Pathway & Other Pathways of Hexose Metabolism22. Oxidation of Fatty Acids: Ketogenesis23. Biosynthesis of Fatty Acids & Eicosanoids24. Metabolism of Acylglycerols & Sphingolipids25. Lipid Transport & Storage26. Cholesterol Synthesis, Transport, & ExcretionSection 3: Metabolism of Proteins and Amino Acids27. Biosynthesis of the Nutritionally Nonessential Amino Acids28. Catabolism of Proteins & of Amino Acid Nitrogen29. Catabolism of te Carbon Skeletons of Amino Acids30. Conversion of Amino Acids to Speicalized Products31. Pophyrins & Bile PigmentsSection 4: Structure, Function and Replication of Infomraitonal Macromolecules32. Nucleotides33. Metabolism of Purine & Pyrimidine Nucleotides34. Nucleic Acid Structure & Function35. DNA Organization, Replication, & Repair36. RNA Synthesis, Processing, & Modification37. Protein Synthesis & The Genetic Code38. Regulation of Gene Expression39. Molecular Genetics, Recombinant DNA, & Genomic TechnologySection 5: Biochemistry of Extracellular and Intracullular Communication40. Membranes: Structure & Function41. The diversity of the Endocrine System42. Hormone Action & Signal TransductionSection 6: Special Topics (will highlight the 16 cases)43. Nuturition, Digestion & Absorption44. Micronutrients: Vitamins & Minerals45. Free Radicals and Antioxidant Nutrients46. Intracellular Traffic & Sorting of Proteins47. Glycoproteins48. The Extracellular Matrix49. Muscle & the Cytoskeleton50. Plasma Proteins & Immunoglobulins51. Hemostasis & Thrombosis52. Red & White Blood Cells53. Metabolism of Xenobiotics54. The Biochemistry of Aging55. Cancer: An Overview56. Clinical Biochemistry57. Biochemical Case HistoriesAppendixThe Answer BankIndexNER(01): WOW
