基本説明
Provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics as applied to drug product development and drug therapy. 5th ed.: 2004.
Full Description
A comprehensive textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics The field's leading text for more than three decadesApplied Biopharmaceutics & Pharmacokinetics, Sixth Edition provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies these principles to drug product development, drug product performance and drug therapy. The revised and updated sixth edition is unique in teaching basic concepts that relate to understanding the complex issues associated with safe and efficacious drug therapy.Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics will help you to:Understand the basic concepts in biopharmaceutics and pharmacokinetics.Use raw data and derive the pharmacokinetic models and parameters that bestdescribe the process of drug absorption, distribution, and eliminationCritically evaluate biopharmaceutic studies involving drug product equivalencyand unequivalencyDesign and evaluate dosage regimens of drugs, using pharmacokinetic andbiopharmaceutic parametersDetect potential clinical pharmacokinetic problems and apply basic pharmacokineticprinciples to solve themPractical problems and clinical examples with discussions are included in each chapter to help you apply these principles to patient care and drug consultation situations. Chapter Objectives, Chapter Summaries, and Frequently Asked Questions along with additional application questions appear within each chapter to identify and focus on key concepts. Most of the chapters have been revised to reflect our current understanding of drug product performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy.
Contents
PrefaceGlossary1. Intrtoduction to Biopharmaceutics and Pharmacokinetics2. Mathematical Fundamentals in Pharmacokinetics3. One-compartment Open Model: Intravenous Bolus Administration 5. Intravenous Infusion6. Drug Elimination and clearance7. Pharmacokinetics of Oral Absorption8. Multiple-Dosage Regimens9. Monlinear Pharmacokinetics10. Physiologic Drub Distribution and Protein Binding11. Drug Elimination and Hepatic Clearance12. Pharmacogenetics13. Physioloic Factors Related to Drug Absorption14. Biopharmaceutc Consideratins in Drug Product Desitgn and In Vitro Drug Product Performance15. Drug Product Performance, In Vivo: Bioavailability and Bioequivalence16. Impact of Drug Product Quality and Biopharmaceutics on Clincal Efficacy17. Modified-Release Drug Products18. Targeted Drug Delivery Symptoms and Biotechnological Products19. Relationship Between Pharmacokeinetics and Pharmacodynamics20. Application of Pharmacokinetics to Clinical Situations21. Dose Adjustment in Renal and Hepatic Disease Appendix A StatisticsAppendix B Applications of Computer in PharmacokinetcsAppendix C Solutions to Frequently Asked Questions (FAQs) and Learning QuestionsAppendix D Guiding Prinicples for Human and Animal ResearchAppendix E Popular Drugs and Pharmacokinetic ParametersIndexNER(01): WOW
