Mucosal Barriers and Host-Microbiota Interplay : Dysbiosis to Barrier Dysfunction

著者名：Yu PhD, Linda Chia-Hui (EDT)

Academic Press（2026/07/06発売）

• 言語：ENG
• ISBN：9780443403064
• eISBN：9780443403071

Description

Mucosal Barriers and Host-Microbiota Interplay: Dysbiosis to Barrier Dysfunction, a volume in Elsevier's new series Hot Topics in Physiology, provides an in-depth exploration of mucosal barriers, including their structure, establishment, and consideration of different diseases and intervention strategies. Published in association with the International Union of Physiological Sciences (IUSP), this is an ideal reference for those researching or studying biology and medicine, particularly gastroenterology. Biotechnological companies working on metagenomics sequencing and analysis may also find this volume useful.As a massive load of commensal microbes, consisting of bacteria, viruses, and fungi resides in the gastrointestinal tract and other mucosal surfaces, collectively termed microbiota, this book provides an update on new and existing knowledge. Mucosal barriers, including the epithelial layers and immune cells act as the frontline to strategically confine these microorganisms and prevent the entry of microbes into the body proper.- Presents the pathophysiology of host-microbiota crosstalks- Explores the unconventional roles of epithelial barrier structures involved in intestinal homeostasis- Teaches how microbiota dysbiosis and barrier dysfunction contribute to disease pathogenesis

Table of Contents

1. Host Barriers against Microbiota: Traditional Views and Recent Advances2. Neonatal Establishment of Microbiome Ecosystem and Intestinal Barrier: How Developmental Programming of Gut Microbiota Impacts Adult Disease Progression3. Epithelial Junctional Proteins for Physical Defense, Cell-Cell Contact, and Polarity Complex4. Unconventional Roles of Tight Junctions in Cell Survival and Ion Transport5. Epithelial Microvilli and Transcellular Permeability in the Cause-and-Effect Relationship between Barrier Dysfunction and Microbiota Dysbiosis6. Wound Healing and Barrier Integrity: Cellular and Molecular Players in Gastric Mucosal Repair7. Mucosal Pathophysiology: The Role of Gut Microbiota Biofilms during Host-Pathogen Interplay8. Antagonism between Gut Microbiota Modulates the Progression of Chronic Hepatitis9. The Role of Microbiome-Mucosal Barrier Interactions in Neoplastic Diseases10. The Interplay of Gut Microbiota and Energy Homeostasis in Obesity-related Diseases11. Refining the Role of Gut Microbiota in the Developmental Programming of Cardiovascular Kidney Metabolic Syndrome12. Interrelationship between Intestinal Immune Cells and Barrier Function in the Development of Neurodegenerative Diseases13. Intestinal Epithelial Cells: Gatekeepers of Gut-Brain Axis, Microbiome, and Beyond14. Epithelial Barriers and Microbiota-Gut-Brain Axis, Microbiome, and Beyond15. The Role of Gut Microbiota in Cancer Development and Translational Modulation Strategies16. Diagnostic and Therapeutic Potentials Targeting the Interplay of Host Barriers and Microbiota in Human Diseases17. The Dietary Restoration of Intestinal Barrier Function by Nutrient-Sensing Receptors18. Dietary Factors and Next-Generation Probiotics for Microbiota Eubiosis and Barrier Fortification