Description
Unlocking Sirtuins: Cellular Biology to Translational Research explores the intricate roles of sirtuins, from basic principles to clinical significance. The book is organized into six parts, covering foundational concepts, roles in aging and metabolism, disease pathology, therapeutic strategies, future research directions, and potential challenges. Topics include the structure and evolution of sirtuins, their mechanisms of action, and their impact on neurodegenerative diseases, cardiovascular health, and cancer. The book also features detailed chapters on sirtuin modulators, drug discovery, the latest technologies and tools in the field, emerging trends, and the challenges, ethical considerations and future directions of sirtuin-targeted therapies.The book's content is complemented by case studies, clinical insights, and step-by-step procedures, offering a comprehensive and practical exploration of the subject. Users will find an in-depth overview of sirtuin biology, bridging fundamental science with clinical applications. This comprehensive resource will serve as an essential resource for researchers, clinicians, and advanced students working across cellular and molecular biology, biochemistry, pharmacology, aging, metabolic disorders, translational medicine, and related fields.- Provides an interdisciplinary overview of sirtuin biology, bridging foundational science with translational research- Facilitates the development of sirtuin-targeted therapies for a variety of diseases, including cancer and neurodegenerative disorders- Highlights cutting-edge tools and technologies for sirtuin analysis- Includes case studies and step-by-step procedures to support scientists in their own research
Table of Contents
Part 1: Introduction to sirtuins1. Sirtuin proteins: structure, functions, and evolutionary insights2. Nad⁺-dependent enzymatic mechanisms and NAD⁺ precursors (NMN, NR)Part 2: Sirtuins and aging3. Sirtuins in senescence, mitochondrial health, and longevity4. DNA repair and genome maintenance via sirtuin pathwaysPart 3: Sirtuins in metabolic regulation5. Sirtuins and energy homeostasis6. Role of sirtuins in glucose and lipid metabolism7. Sirtuins in caloric restriction and fasting responsesPart 4: Sirtuins in disease pathology 8. Sirtuins in neurodegenerative diseases9. Sirtuins in cardiovascular health10. The role of sirtuins in cancer progression11. Sirtuins in inflammation and autoimmunityPart 5: Therapeutic applications12. Sirtuin modulators: small molecules and natural compounds13. Sirtuin-targeted therapies: current challenges, clinical trials, and future directions14. Translational perspectives in drug discoveryPart 6: Future directions and challenges15. Emerging trends in sirtuin research16. Technological advancements in sirtuin analysis17. Experimental tools for sirtuin modulation: from CRISPR to chemical biology18. Ethical and clinical implications of sirtuin therapies
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