Description
Protein Serine/Threonine Kinases in Neurodegenerative Disorders discusses protein kinase inhibitors and their potential role in modulating and treating neurodegenerative diseases. The book introduces protein kinases and inhibitors and includes detailed discussions on different types of kinases, including protein kinase C (PKC), AMP-activated protein kinase (AMPK), death-associated protein kinase 1 (DAPK1), cyclin-dependent kinases (CDKs), glycogen synthase kinases (GSKs), Rho-associated protein kinase (ROCK), microtubule affinity regulating kinases (MARKs), mammalian target of rapamycin (mTOR), leucine-rich repeat kinase 2 (LRRK2), PTEN-induced kinase 1 (PINK1), and dual-specificity tyrosine phosphorylation-regulated kinase (DYRK), and their roles in neurodegenerative disease, potential inhibitors, and therapeutic mechanisms.This book features 23 chapters written by renowned experts in the field of kinases. It explores novel targets modulated by protein kinases, including noncoding RNAs (ncRNAs) and mitogen-activated protein kinases (MAPKs) activated by tyrosine receptor kinases, and their roles in neurodegeneration. It also discusses the nexus between glycogen synthase kinases (GSKs) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) and their role of metabolic regulation in neurodegeneration. The modulatory effects of protein kinase B (PKB/AKT) pathways in various neurodegenerative disorders, particularly Parkinson's disease, are also examined. This book sheds light on bioactive compounds from natural products that target kinases and explains the role of different kinases in various pathogenic pathways and mechanisms involved in neurodegeneration, including regulated cell death, autophagy, synaptic dysfunction, and neuroinflammation.- Explores how kinases regulate cellular processes and contribute to neurodegenerative disorders- Highlights emerging therapies targeting these kinases, empowering readers with actionable knowledge- Includes case studies that demonstrate kinase-targeted strategies in neurodegenerative disorders
Table of Contents
1. Protein serine/threonine kinases: An overview2. Protein kinase C (PKC) in Neurodegenerative disorders3. AMP-activated protein kinase (AMPK) in neurodegenerative disorders4. Death-associated protein kinase 1 (DAPK1) in neurodegenerative disorders5. The mitogen-activated protein kinases (MAPKs) activated by tyrosine receptor kinases (Trk receptors for neurotrophin) and their roles in neurodegeneration6. Cyclin-dependent kinases (CDKs) in neurodegenerative disorders7. Unlocking the Potential of GSK-3β Inhibitors in Neurodegenerative Disease Prognosis: Insights from Glucagon-like Peptide-1 Receptor Agonist Effects8. Rho-Associated Coiled-Coil-Containing Protein Kinase (ROCK) in neurodegenerative disorders9. Microtubule Affinity-Regulating Kinases (MARKs) in neurodegenerative disorders10. Mammalian target of Rapamycin (mTOR) in neurodegenerative disorders11. Leucine-Rich Repeat Kinase 2 (LRRK2): A Potential Target in Parkinson's Disease and Beyond12. PTEN-induced kinase 1 (PINK1) in neurodegenerative disorders13. Dual-specificity Tyrosine phosphorylation-Regulated Kinase-1A (DYRK1A) in Neurodegenerative disorders14. AKT pathway as therapeutic target in neurodegenerative diseases: mechanisms and implications15. Targeting AKT pathways: A potential therapeutic target for Parkinson's disease16. Non-coding RNAs Regulating Serine/Threonine Kinases in Neurodegeneration17. Protein serine/threonine signaling pathways: Opportunities and translational perspectives18. Natural Products in Neurodegenerative Diseases: Role of Serine/Threonine Kinases19. Targeting autophagy-related serine/threonine kinases to combat neurodegenerative disorders20. Targeting regulated cell death-related serine/threonine kinases to combat neurodegenerative disorders21. Splicing Kinases in Neuronal Health and Neurodegeneration22. Balancing Efficacy and Safety: Protein Kinase Inhibitors and Drug-Induced Liver Injury23. Targeting serine/threonine kinases: Therapeutic innovations for neurodegenerative disorders
