Description
Novel and Innovative Drug Delivery Systems to Overcome Chemoresistance in Human Malignancies addresses the critical challenge of cancer chemoresistance, synthesizing insights from cancer biology, molecular biology, biotechnology, and nanotechnology. The book explores the complex mechanisms underlying drug resistance, including alterations in key signaling pathways and the tumor microenvironment's role in cancer cell survival. It highlights advancements in drug delivery technologies, such as nanomedicine and biomimetic strategies, which enhance drug targeting and minimize off-target effects. The integration of techniques like CRISPR-Cas9 and artificial intelligence in developing next-generation therapies is also emphasized. For an academic audience, this book serves as an essential resource to foster interdisciplinary collaboration in cancer research. It equips researchers, clinicians, and industry professionals with the knowledge needed to navigate the evolving landscape of cancer therapeutics, addressing critical challenges in drug delivery and chemoresistance to improve patient outcomes.- Combines knowledge from cancer biology, molecular biology, biotechnology, and nanotechnology to provide a comprehensive understanding of chemoresistance and innovative drug delivery systems- Showcases the latest advancements in drug delivery methods, including nanomedicine and biomimetic strategies, emphasizing their potential to enhance therapeutic efficacy and minimize off-target effects- Presents solutions to overcome cancer chemoresistance, equipping researchers, clinicians, and industry professionals with essential knowledge to navigate the evolving landscape of cancer therapeutics
Table of Contents
1 Exploring chemoresistance mechanisms and innovative drug delivery approaches in effective cancer therapy2 Molecular interplay of hypoxia, aberrant angiogenesis, and immune suppression in cancer chemoresistance3 Impact of hypoxia, angiogenesis, and immunosuppression in chemoresistance4 Design and applications of smart biomaterials for anticancer drug delivery systems5 Revolutionizing precision oncology: Combating chemoresistance with nanorobotics6 Advanced drug delivery strategies: Nanoparticles, liposomes, dendrimers, and smart biomaterials7 Epigenetic modulations in cancer chemoresistance: Harnessing nanotechnology for targeted therapy8 Advancements in cancer immunotherapy: Targeting the tumor immune microenvironment (TIME)9 Near-infrared responsive photothermal-immunotherapy for overcoming chemoresistance in cancer therapy10 Combating chemoresistance through RNA-based therapeutic approaches: A mechanistic insight11 Therapeutic potential of drug repurposing in reversing chemoresistance12 Ion channels in chemoresistance: A mechanistic overview and CRISPR-based therapeutic strategies13 CRISPR/Cas9 and gene editing approaches as a solution for chemoresistance14 Clinical applications and emerging challenges of novel drug delivery systems15 Exosome and extracellular vesicle-based therapeutics to overcome cancer chemoresistance16 Preclinical strategies for investigating drug delivery platforms17 Artificial intelligence and machine learning approaches in rational drug design to overcome cancer chemoresistance18 Chemoresistance in modern oncology: A multilayered network of signaling, plasticity, and tumor microenvironmental interactions
