Description
Unlock the future of individualized patient care with this guide to mastering the interdisciplinary synergy of next-generation sequencing, clinical diagnostics, and ethical frameworks that define the new era of precision medicine.
The field of genomics has witnessed remarkable growth over the past few decades, fundamentally altering the landscape of healthcare and medical research. The rapid advancement of genomic technologies, particularly next-generation sequencing and the growing understanding of the human genome, has opened new frontiers in diagnostics, treatment, and prevention. Genomics now sits at the intersection of molecular biology, bioinformatics, pharmacology, and clinical medicine, forming the foundation of precision healthcare. This book explores the transformative impact of genomics on modern medicine, from foundational principles of genetics to cutting-edge clinical applications. It examines how genomic technologies are reshaping diagnosis and treatment across conditions such as cancer, rare diseases, and infectious diseases, while highlighting the rise of precision medicine—an approach that tailors therapies based on individual genetic profiles. The book also addresses key challenges in integrating genomic data into healthcare systems, including ethical considerations in genetic testing, genomic counseling, and evolving healthcare policy. With a global perspective, it provides insights into the opportunities and complexities of implementing genomic medicine across diverse healthcare environments.
Table of Contents
Preface xxiii
1 The Fundamentals of Genetics and Genomics: A Primer for Healthcare Professionals 1
K. Haripriya, Swetha Kumari Koduru and K. Nandini
2 From Gene Discovery to Clinical Applications: The Journey of Genomic Research 39
Bolaji Fatai Oyeyemi, Muhammad Abiodun Sulaiman, Saheedat Olabisi Dauda, Habeebat Adekilekun Oyewusi, Oluwatosin Olubunmi Oladipo and Habeebulahi Ajibola Adekilekun
3 Precision Medicine: Tailoring Treatments to Genetic Profiles 67
Ashok Thulluru, Goutham Yerrakula, Nawaz Mohammed, Reshma Tadipatri and Varun Srighakollapu
4 Genomic Technologies in Diagnostic Medicine: Advances and Applications 97
Pradeep Natarajan
5 Pharmacogenomics: How Genetic Information Influences Drug Response 139
G. Avinash Kumar, P. Pravallika, V. Thirumalai, Chandrashekar Thalluri and Sarad Pawar Naik Bukke
6 Ethical, Legal, and Social Implications of Genomic Data in Healthcare 171
M. Reddy Sailaja, Swetha Kumari Koduru and R. Venkata Raghava Reddy
7 The Role of Genomics in Rare and Noncommunicable Diseases 201
S.K. Abdul Rahaman, Aman Sisodia, Ananda Kumar C.H., Padmavathi Sakinala and Ajay Bommareddy
8 Cancer Genomics: Innovations in Diagnosis, Prognosis and Therapy 233
Habeebulahi Ajibola Adekilekun, Olorunshola Dave Omodamiro, Ngozi Kalu Achi, Habeebat Adekilekun Oyewusi and Racheal Majekodunmi Omodamiro
9 Genomic Research in Infectious Diseases: Impact and Advances 255
Ananda Kumar Chettupalli, Aman Sisodia, Rajendra Kumar Jadi, Akiful Haq and Nagarani Kagithala
10 Genomics of Prenatal and Paediatric Diseases: Early Detection and Intervention 295
Priyanka and Ayush Madan
11 Integrating Genomic Data into Electronic Health Records (EHRs) 351
Raju C., Thrisha Lakkireddy, Reddi Mohan Naidu K., Sivasubramanyam Medasani and Bukke Pasunath Naik
12 Genomic Counseling: Navigating the Complexities of Genetic Risk and Inheritance 373
Mudigubba Manoj Kumar, Queeni Sharoon Melam, Mohammed Azhar Hussain, Vishnuvara V. Tummeeti and Akkiraju Sudheer
13 Healthcare Policy and Genomics: Shaping the Future of Health Care Systems 419
A. Revathi, B. Princy, K. Janani, M. Divya, B. Lokeshwari and P. Saranraj
14 Patient Perspectives and Experiences with Genomic Testing 441
Safa A. Abdalla
15 Global Prospectives on Genomic Healthcare: Opportunities and Challenges 463
Shaik Harun Rasheed, Kondapuram Parameshwar, G. Buela Priyanka, Laith Hamza Samein and Ravi Kumar Vakkalagadda
Acknowledgment 485
References 485
Index 489
