Description
Capsaicin, the Pungent Principle in Hot Pepper: From Basic Pharmacology to Therapeutic Applications explores capsaicin's biological and pharmacological characteristics, from its discovery and isolation to its receptor identification and antagonists. The book's structure is divided into three sections, starting with the historical development of research on capsaicin. This foundational section provides a thorough understanding of the compound's journey from a simple pungent ingredient to a significant element in pharmacological studies. The second part of the book delves into capsaicin's biological effects and pharmacology, covering areas such as nociception, pain, salivary secretion, body temperature regulation, and blood pressure regulation.Finally, the book examines the clinical applications of capsaicin, discussing potential future developments in desensitization, pain relief, injections, effects on the tumor microenvironment, appetite control, and longevity. This book is invaluable for pharmacology researchers and clinicians in pain management and cancer, offering insights into the unique characteristics and therapeutic potential of capsaicin.- Provides historical background on capscaicin research, from the domestication all the way to the 2021 Nobel Prize winning research- Explores the scientific basis of longevity use of capsaicin- Covers the state-of-art on the biology, pharmacology, and potential clinical applications of capsaicin
Table of Contents
SECTION 1: CAPSAICIN AND ITS RECEPTOR: HISTORY, CHEMISTRY AND BIOLOGICAL BACKGROUND1. A brief history of capsaicin (hot pepper)2. The hunt for the capsaicin receptor3. The discovery of Resiniferatoxin4. Breakthrough: molecular cloning of the capsaicin receptor TRPV1 in 19975. Brain TRPV1: a controversial topic.6. TRPV1 antagonistsSECTION 2: THE BIOLOGICAL EFFECTS AND PHARMACOLOGY OF CAPSAICIN7. The pharmacology of capsaicin I – Nociception and Pain8. The pharmacology of capsaicin II – Salivary secretion9. The pharmacology of capsaicin III - Body temperature regulation.10. The pharmacology of capsaicin IV - Capsaicin and blood pressure regulation.11. Capsaicin analoguesSECTION 3: CURRENT AND PERSPECTIVE USE OF CAPSAICIN IN CLINICAL SETTINGS12. Capsaicin desensitization13. High-dose capsaicin path for pain relief.14. Site-specific capsaicin injections for pain relief.15. Intravesical capsaicin for detrusor hyperreflexia.16. Capsaicin-sensitive afferents in the tumor microenvironment.17. Dietary capsaicin: appetite control, obesity.18. Capsaicin for longevity19. Concluding remarks
