Description
Revolutionize your approach to oncology with this guide to mastering the interdisciplinary intersection of green chemistry and clinical research, where polysaccharide-based innovations provide a safer, biocompatible, and sustainable frontier for cancer treatment.
Cancer continues to be a major global health issue, impacting millions of individuals annually. Although traditional cancer treatments have improved, there is a rising demand for alternative and complementary medicines that may provide advantages with fewer side effects. Polysaccharides, which are complex sugars found in plants, fungi, and microbes, are considered for cancer research and treatment because of their many biological effects, compatibility with living organisms, and low toxicity. In recent years, the area of polysaccharide-based cancer treatment has seen substantial expansion. This book provides a thorough summary of the present status of research and advancements in polysaccharide-based cancer treatment. It delves into the interdisciplinary and rapidly evolving field of biomedical research that intersects with pharmaceutics, oncology, and materials science. There is a growing focus on treatment methods that are both more sustainable and safer, in line with the ideas of green chemistry and personalized medicine. This book documents a crucial stage in the advancement of various fields, including materials science, biotechnology, and clinical oncology, offering new therapies that are better aligned with the human body and the environment.
Readers will find the volume:
- Introduces the structural features, properties, and biological effects of polysaccharides that are pertinent to cancer research and treatment;
- Examines recent progress in polysaccharide-based drug delivery technologies, immunomodulatory effects, and targeted therapeutic strategies;
- Showcases case studies, clinical trials, and translational research that illustrate the efficacy of polysaccharides in enhancing treatment results and patient well-being;
- Discusses obstacles, possibilities, and future directions for advancing research using polysaccharide-based cancer treatments;
- Acts as a resource for anyone interested in the function of polysaccharides in cancer research and therapy, promoting multidisciplinary cooperation.
Audience
Academics, researchers, and professionals in oncology, biomedical engineering, nanotechnology, and drug delivery systems, specifically cancer researchers, biotechnologists, pharmaceutical scientists, and clinicians interested in biomaterials and advanced therapeutic strategies.
Table of Contents
Preface xvii
Acknowledgment xix
1 Introduction to Polysaccharides in Cancer Therapy: Unveiling the Therapeutic Potential 1
Suvarna Yenduri and Naga Prashant K.
1.1 Introduction 2
1.2 Role of Polysaccharides in Current Cancer Therapy 6
1.3 Challenges 16
1.4 Future Directions and Potential Therapies 17
1.5 Conclusion 17
2 Structural Insights and Biophysical Properties of Polysaccharide Biomaterials for Enhancing Cancer Therapy 25
Shahnawaz Ahamd Bhat, Zeenat Islam, Shazia Shaheen Mir and Luqman Jameel Rather
2.1 Introduction 26
2.2 Structural Aspects of Polysaccharides 28
2.3 Biophysical Properties Relevant to Cancer Therapy 31
2.4 Interaction Mechanisms with Cancer Cells and the TME 34
2.5 Polysaccharide-Based Delivery Systems for Cancer Therapy 37
2.6 Challenges and Future Perspectives 42
2.7 Conclusion 47
3 Inulin-Based Nanoparticles: Advancing Cancer Therapeutics through Biopolymer Innovations 57
Tariq Ahmad Mir, S. Wazed Ali and Showkat Ali Ganie
3.1 Introduction 58
3.2 Chemistry and Structure of Inulin 59
3.3 Biodegradability: Advantages for Biomedical Applications 61
3.4 Synthesis and Fabrication of Inulin-Based Nanoparticles 62
3.5 Applications in Cancer Therapy 64
3.6 Mechanisms of Action in Cancer Cells 66
3.7 Case Studies and Examples 67
3.8 Challenges and Limitations 73
3.9 Emerging Trends and Future Perspectives 74
3.10 Conclusion 76
4 Chitosan: Biomedical Applications and Cancer Therapeutic Potential 87
Md Aamir Aftab, Iftkhar Ahmad, Asma Fatima and Saiqa Ikram
4.1 Introduction 88
4.2 CS as Stabilizer for NPs 90
4.3 Biomedical Applications of CS 91
4.4 CS in Cancer Therapeutics 99
4.5 Modifications of CS and their Therapeutic Application 106
4.6 Strategies for Enhancing Bioavailability 108
4.7 Challenges and Future Prospects 109
4.8 Conclusion 110
5 Gum Acacia Synthetic Routes for Anticancer Treatment Development 121
Tahira Bashir, Muhammad Ahsan Ullah Danish, Farhat Bano, Tayyaba Ijaz, Ji-Xin Tang and Muhammad Asmat Ullah Saleem
5.1 Introduction 122
5.2 Basic of Gum Acacia (Types, Structure, Chemical, and Physical Nature) 125
5.3 Immunomodulatory Role of Gum Acacia 128
5.4 Antitumor Properties of Gum Acacia 129
5.5 Advancement in Gum Acacia Applications 131
5.6 Current Challenges and Future Prospective 135
5.7 Conclusion 136
6 Cyclodextrins: Inclusion Complexes and Drug Delivery in Cancer Therapy 149
Mohd Hafizur Rehman Ansari, Mohan Lal and Ravindra K. Rawal
6.1 Introduction 150
6.2 Impact of CDs on Properties of Formulations 152
6.3 Application of CDs 155
6.4 DD Approaches 162
6.5 CDs-Based Nanostructures in Cancer Therapy 169
6.6 CDs as Carriers of the Anticancer Drug Development 170
6.7 Future Perspective/Direction 182
6.8 Conclusion 183
7 Hyaluronic Acid: Targeted Delivery Strategies for Anticancer Agents 193
Atharva Anand Mahajan, Gauri Panzade, Souhardya Bandyopadhyay and Subhrojyoti Ghosh
7.1 Introduction 194
7.2 HA: Structure and Biological Role 198
7.3 Mechanism of Targeting Via HA 200
7.4 HA-Driven DDS 203
7.5 HA Modified Delivery Vehicles for Specific Anticancer Agents 206
7.6 Challenges in HA-Based Targeted Delivery 208
7.7 Clinical Applications and Current Advances 211
7.8 Challenges in Advancing HA-Based Delivery Systems from Preclinical to Clinical Stages 213
7.9 Conclusion 214
8 Beta Glucagon: Immunomodulatory Effects and Anti-Cancer Applications 223
Mehwish Rafiq, Muhammad Asmat Ullah Saleem, Ali Raza, Abdullah Ahmed Butt, Farhat Bano, Muhammad Ahsan Ullah Danish and Ji-Xin Tang
8.1 Introduction 224
8.2 Importance of Immunomodulatory and Anti-Cancer Properties 226
8.3 Understanding Beta-Glucan 227
8.4 Methods of Extraction 232
8.5 Methods of Purification 234
8.6 Beta-Glucan Immunomodulatory Effects 235
8.7 Anti-Cancer Properties 241
8.8 Beta-Glucan and the Gut Microbiota 244
8.9 Advances in Beta-Glucan Research and Applications 250
8.10 Challenges and Future Directions 254
8.11 Conclusion 258
9 Guar Gum: Structural Modification Strategies for Therapeutic Anticancer Effect 267
Bushra Munir, Iqra Noor, Maimoona Nazir, Abdul Ghaffar, Shazba Aziz, Sadia Falak and Hunaira Nasreen
9.1 Introduction 268
9.2 Structure and Composition of Guar Gum 270
9.3 Physical and Chemical Properties of Guar Gum 271
9.4 Chemical Modification of Guar Gum 275
9.5 Enzymatic Modifications of Guar Gum 279
9.6 Characterization Techniques 281
9.7 Application of Guar Gum in Health Management 282
9.8 Drug–Polymer Interaction 288
9.9 Comparative Evaluation of Guar Gum with Other Biopolymers 289
9.10 Synergistic Potential of Guar Gum Derivatives in Combinatorial Cancer Treatments 290
9.11 Future Prospective 293
9.12 Conclusion 293
10 Agarose: Nanostructured Platforms for Drug Delivery in Cancer Treatment 301
Haleema Ahmad and Mohd Salik Usmani
10.1 Introduction 302
10.2 Nanostructured Platforms for Drug Delivery 304
10.3 Synthesis and Fabrication of Agarose-Based Nanostructures 307
10.4 Functionalization and Modification of Agarose Nanostructures 311
10.5 Mechanisms of Drug Delivery in Cancer Treatment 315
10.6 Applications of Agarose Nanostructures in Cancer Therapy 319
10.7 In Vitro and In Vivo Studies 323
10.8 Clinical Translation and Challenges 326
10.9 Scalability and Regulatory Challenges 328
10.10 Future Directions and Emerging Trends 330
10.11 Conclusion 332
11 Pectin: Chemical Functionalization for Targeted Cancer Treatment 339
Shazia Shahen Mir, Shahnawaz Ahmad Bhat, Md. Saddam, Zeenat Islam and Luqman Jameel Rather
11.1 Introduction 340
11.2 Structure and Chemistry of Pectin 341
11.3 Functionalization and Modification of Pectin 344
11.4 Applications in Targeted Cancer Therapy 345
11.5 Mechanisms of Action in Cancer Cells 348
11.6 Challenges and Limitations 349
11.7 Future Perspectives 351
11.8 Conclusion 354
12 Alginate Nanoparticles: Advances in Cancer Therapy 365
Andleeb Amin and Showkat Ali Ganie
12.1 Introduction 366
12.2 Structure and Chemistry of Alginate 367
12.3 Synthesis of Alginate Nanoparticles 368
12.4 Application in Cancer Therapy 371
12.5 Challenges and Future Directions 383
12.6 Conclusion 385
References 386
Index 393
