Description
Despite extraordinary therapeutic advances since the discovery of insulin 100 years ago, diabetes prevalence continues to rise and significant challenges remain. Modern Diabetology: Basic Science and Clinical Practice provides a concise, one-stop reference that consolidates rapidly evolving research and clinical practice guidelines for today's endocrinologists, general surgeons, internists, and primary care physicians.- Provides up-to-date coverage of basic science, translational advances, and clinical management in one accessible text, serving as a critical reference for practitioners navigating fast-moving developments in the field- Features 24 chapters authored by internationally recognized experts in diabetes research and clinical practice- Offers in-depth updates on rapidly advancing areas including MODY, hormonal biology, Types 1 and 2 diabetes genetics, immune mechanisms, and oxidative stress and complications- Covers cutting-edge therapeutic strategies such as SGLT2 inhibitors, GLP1 - receptor agonists, glucose sensors and pumps, stem cell therapy, and pancreas and islet transplantation- Any additional digital ancillary content may publish up to 6 weeks following the publication date
Table of Contents
SECTION I Regulation of Gene Expression, Hormone Synthesis, and Hormone SecretionChapter 1 Pancreatic Development in the Context of DiabetesChapter 2 Glucagon: From Gene Regulation to SecretionChapter 3 Insulin Production, Processing, and SecretionChapter 4 Incretins: From Gene Expression to Secretion and Action of GLP-1 and GIPSECTION II Hormone ActionChapter 5 Glucagon Synthesis, Secretion, and Mechanisms of ActionChapter 6 Insulin Structure and FunctionChapter 7 Common Mechanisms of Insulin Signaling, Action, and ResistanceChapter 8 Insulin Receptor Structure and FunctionChapter 9 Insulin Action in Liver, Skeletal, Muscle, and Adipose Tissue: A Focus on HumansChapter 10 Insulin Action in the BrainChapter 11 Insulin Action in the Cardiovascular SystemChapter 12 Metabolic Regulation by Adipokines, Hepatokines, and MyokinesSECTION III Genetics of DiabetesChapter 13 Genetics of Monogenic Forms of DiabetesChapter 14 Genetics of Type 1 DiabetesChapter 15 Genetics of Type 2 DiabetesSECTION IV Type 1 DiabetesChapter 16 Spotlight on the Pathology of Type 1 DiabetesSECTION V Type 2 DiabetesChapter 17 Heterogeneity of Type 2 Diabetes MellitusChapter 18 Cystic Fibrosis–Related DiabetesSECTION VI Complications of DiabetesChapter 19 Intranuclear Beta Cell Nrf2 Expression in Type 2 Diabetes and the Potential Use of Glutathione Peroxidase Mimetics for Early TreatmentChapter 20 Diabetic Retinal DiseaseChapter 21 Understanding Diabetic Neuropathy: From Pathophysiology to Therapeutic TargetsSECTION VII Pharmacology and DrugsChapter 22 SGLT2 Inhibitors and Slowing Kidney Disease Progression From DiabetesChapter 23 Advanced Technology in Diabetes: Sensors and PumpsChapter 24 Pancreas and Islet Cell Transplantation for DiabetesChapter 25 Stem Cell–Derived Islet Therapy for Type 1 Diabetes
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