Description
Immunological Aspects of Preterm Birth, a volume in the Reproductive Immunology book series, bridges reproductiveimmunology of preterm birth to subtypes, phenotypes, and bedside prevention and treatment. This book reviews therole of the different immune mechanisms during pregnancy leading to preterm birth and fetal programming effects thatare connected to maternal immune activation. This book also discusses immune cells and their products, cytokines andchemokines, as central for the success of the pregnancy, from the process of implantation to parturition and the effects ofthe changes on fetal programming.While our knowledge on the role of immune cells and the inflammatory process in preterm birth has grown exponentiallyin the last 10 years, connecting basic science to clinical science and development of new therapeutics has not progressedas rapidly. This book assists researchers in understanding the basic immunologic mechanisms and inflammatory processesassociated with preterm birth and fills an urgent need for the development of therapeutics in this space.• Provides a detailed evaluation of preterm birth subtypes and phenotypes• Evaluates each immune cell type and its function in maternal peripheral system, placenta, and fetus• Gives the biological background for understanding the clinical aspects, including treatment venues and effects on fetalprogrammingAbout the Editor
Table of Contents
1 Preterm labor, preterm birth, and prematurity: Molecular and clinical phenotypes- Sahar Khoshravesh, Alison DiSciullo, Irina Burd2 Screening, diagnosis, and therapeutic approaches to preterm labor- Metehan Imamoglu, Paola Abi Habib, Ozhan M. Turan3 Cellular immunology of preterm labor and birth and its potential utility for biomarker discovery- Nardhy Gomez-Lopez, Dustyn Levenson, Seungbaek Lee, Barbara Neshek, Jose Galaz4 Understanding preterm birth: The role of infection and inflammation- Kristina Adams Waldorf, Celeste Coler5 The role of macrophages in preterm birth- Yang Liu, Meredith Kelleher, Sudeshna Tripathy, Irina Burd6 T cells, placentation, gestational length and an evolutionary perspective relevant to preterm birth- Elizabeth A Bonney7 Spontaneous preterm birth: Immunoperinatology perspective- Jun Lei8 Exosomes in reproductive biology and medicine- Ramkumar Menon, Ananth Kumar Kammala9 Vaginal microbiome and preterm birth- Jacques Ravel, Anna Maya Powell10 Viral infections and preterm birth- Vanusa Pousada da Hora, Jiahui Ding, Gil Mor11 Environment and immune interactions in preterm birth- Fatemeh Biroon, Courtney Townsel12 Placenta: Window into neonatal health- Liza Konnikova, Kerri St Denis, Oluwabunmi Olaloye13 Spontaneous preterm birth: Current therapies and opportunities for the future- Sarah Boudova, Moti Gulersen14 Special considerations: Transplant in pregnancy- Allison Lankford
