Description
Unlocking the secrets of extracellular vesicles and exosomes: A journey into the cutting-edge frontier of cellular communication provides a comprehensive overview of the latest advances and research on extracellular vesicles (EVs) and exosomes. The book begins with a historical introduction to the field and how this has evolved since EVs were first observed, before exploring their cellular mechanisms and approaches to study their isolation, characterization, and function. It then delves into exosomes in health and disease, considering their role across cancer, regenerative medicine, neurological disorders, and metabolic disorders, highlighting their potential as biomarkers for disease diagnosis. The book moves on to discuss cutting-edge technology for the engineering of EVs and exosomes, considering how the integration of AI, machine learning, and nanotechnology can be utilized to expand the therapeutic capabilities of EV and exosome-based applications. It then closes with chapters covering novel applications in nutraceutical and cosmetic production, and a look towards the future potential of EVs and exosomes. Unlocking the secrets of extracellular vesicles and exosomes offer a thorough exploration of EV and exosome research, covering various dimensions from basic science to clinical applications and future perspectives. It is an ideal guide for researchers working across a diverse range of disciplines, including cell biology, molecular biology, biotechnology, therapeutics, and biomedicine.- Explores the impact of exosomes across a range of diseases, considering their potential for regenerative medicine, targeted drug delivery, and personalized therapeutics- Features techniques for isolation, characterization, and functional assessment of EVs, including ultracentrifugation, size exclusion chromatography, electron microscopy, nanoparticle tracking analysis, and functional assays- Addresses the engineering of EVs and exosomes and the integration of AI, machine learning, and nanotechnology- Includes future prospects for the field, alongside predicted breakthroughs, challenges, and ethical considerations
Table of Contents
Section 1 Extracellular vesicles/exosomes as novel sources of cellular communication1. Historical context and the evolution of exosome research2. The cellular machinery behind exosome formation3. Exosomes as messengers: intercellular communication4. Exosomes: essential messengers in intercellular communication5. Exosomes as cellular couriers: the mechanisms of intercellular messagingSection 2 Extracellular vesicles/exosomes: methods and protocols6. Comprehensive approaches to isolation, characterization, and functional assessment of extracellular vesiclesSection 3 Extracellular vesicles/exosomes in health and diseases: Potential applications7. Exosomes as biomarkers for disease diagnosis8. The intricate interplay between cancer cells and exosomes9. Advancements in stem cell therapy facilitated by exosomes10. Crossing the blood–brain barrier: exosomes in neurological research11. Exosomes as vectors across the blood–brain barrier in neurological research12. Unraveling the role of exosomes in modulating immune responses13. The immunological impact of exosomes: modulation and mechanisms14. Exploring the link between exosomes and metabolic diseases15. Role of exosomal microRNAs in anticancer drug resistance and tumor angiogenesis16. Health implications of retinoic acid in exosome biogenesis, secretion, and uptake17. Exosomes in aging and longevitySection 4 Engineering and scaling up extracellular vesicles and exosomes production: Medicine, nutraceuticals, cosmetics, and novel applications18. Cutting-edge technology for extracellular vesicles and exosomes production: future prospects19. Novel application of extracellular vesicles and exosomes in nutraceutical and cosmetic production20. Ethical considerations, challenges, and the road ahead: exosomes in the next decade
