Description
Epigenetic Regulations in Gastrointestinal Cancers offers a comprehensive exploration of the genomic and epigenomic alterations that underpin the aggressive nature of gastrointestinal (GI) cancers. . By synthesizing the latest research and insights into the role of the tumor microenvironment and cellular signaling pathways, this book aims to elucidate the multifaceted nature of GI cancer neoplasia and propose innovative therapeutic strategies. Addressing critical challenges in GI cancer research and treatment, this book serves as a vital resource for researchers and clinicians striving to bridge the gap between basic research and clinical application. It tackles the complexities of GI cancer mechanisms by integrating knowledge from diverse fields, thereby providing a holistic understanding essential for effective therapeutic development. Through real-world case studies and expert contributions, the book highlights successful treatment regimens that leverage epigenetic insights, thereby fostering dialogue among multidisciplinary teams and promoting collaborative approaches to cancer care. Moreover, the book emphasizes the importance of staying abreast of rapid advancements in the field of cancer research. With contributions from leading experts and an accompanying online platform featuring interactive resources, readers will have access to the latest insights and developments in GI cancer research. By identifying specific epigenetic targets and innovative strategies for overcoming treatment resistance, this book aspires to enhance patient outcomes in GI cancers and contribute to the ongoing evolution of personalized medicine in oncology.- Provides an in-depth analysis of the various epigenetic changeds that contribute to the aggressiveness of gastrointestinal cancers- Bridges the gap between fundamental research findings and their clinical implications, offering case studies and expert insights that illustrate successful therapeutic strategies- Emphasizes the importance of multidisciplinary collaboration in cancer research and treatment, presenting contributions from experts across various subfields
Table of Contents
A. Introduction to epigenetics changes in GI cancers1. Basics of epigenetics in various GI cancers2. Overview of epigenetic changes in cancer related to GI system3. DNA methylation4. Histone modifications5. Non-coding RNAs6. Silencing of tumor suppressor genes7. Activation of oncogenes8. Genomic instability9. Tumor heterogeneity10. Desmoplastic environmentB. Role of epigenetics in tumor progression and influences on therapy resistance11. Evasion of apoptosis12. Promotion of angiogenesis13. Stimulation of metastasis14. Activation of alternate signaling pathways15. Epigenetic modification in cancer stem cell (CSC) in GI cancers16. Mechanisms of drug resistance17. Immune Evasion18. Epigenetic alterations in treatment response19. Strategies for overcoming resistanceC. Exosomes and epigenetic regulation20. Role of exosomes in GI cancers21. Impact on tumor microenvironment22. Exosome-derived biomarkers and therapiesD. Current and Emerging Epigenetic Therapies and Future Directions23. Epigenetic biomarkers and scientific evidence24. Epigenetic drugs25. Challenges and opportunities in epigenetic therapy26. Emerging trends in epigenetic clinical research27. Integrating epigenetics with other GI cancer treatments
