Description
Natural Product Drug Discovery: Highly Anticipated Natural Molecules, a new volume in the Drug Discovery Opinion series, provides a comprehensive examination of the role of natural products in innovative drug development. The book addresses the significant challenges that highly active natural molecules face in the drug development process, including issues related to bioavailability and potency. Sections present analyses of various classes of natural products, including polysaccharides, volatile oils, and diterpenoids, exploring their chemical properties, biological activities, and potential clinical applications. Each chapter, written by leading experts, offers insights into structural modification techniques, naturally sourced inhibitors, and the application of green biomanufacturing strategies.It will serve as an essential resource for researchers, pharmacologists, and industry professionals involved in natural product drug discovery. Readers will find the necessary information to navigate the complexities of the field, emphasizing the integration of traditional knowledge with modern scientific approaches. Through a thorough understanding of these natural compounds, this book aims to contribute to the advancement of therapeutic innovations in pharmacotherapy.- Provides a comprehensive analysis of natural products' chemical properties and biological activities for informed drug development- Explores challenges and solutions in the commercialization of highly active natural molecules- Features expert contributions that offer insights into structural modification and green biomanufacturing strategies- Includes case studies that illustrate successful applications of natural products in therapeutic contexts- Serves as an essential resource for researchers and professionals in natural product drug discovery and pharmacotherapy
Table of Contents
1. Highly Anticipated Natural Molecules2. The Key Technology in Drug Discovery: Structural Modification of Natural Products3. Naturally Sourced Sodium-Glucose Co-transporter 2 Inhibitors for Hypoglycemic: From Phlorizin to Dapagliflozin4. Polysaccharides from TCM as an Important Resource of New Drugs for Antiosteoporosis and Neurodegenerative Diseases5. Drug Discovery from Daphnane-type Diterpenoids: A Balance Between the Anti-HIV Effect and Toxicity6. The Promising Future of Sesquiterpenoids: A Potential Source of New Drugs7. Tussilagone as a Potential Therapeutic Candidate Against Inflammation-Related Diseases8. Right Time for Drug Development from Volatile Oils9. Natural Products in Alzheimer's Disease10. The Discovery, Synthesis, and Bioactivities of Marine Sesquiterpene Hydroquinones/Quinones11. Cardiac Glycoside: A Potential Antineoplastic Candidate from a Medication of Heart Failure and Atrial Arrhythmia12. Natural Products as Potential Neuroprotective Agents for Ischemic Stroke13. Key Strategy for Drug Development: Green Biomanufacturing of Active Natural Products14. Research and Development of the Anti-Tumor Star Molecule Taxol15. Bile Acids: Dual Facets as Modulators and Targets in Natural Product Drug Discovery16. Natural Cephalotane Alkaloids from Cephalotaxaceae as a Source of New Anticancer Drugs17. Computation-Enabled Natural Products Drug Discovery18. Active Metabolites Derived from Microorganisms of Extreme Environments
