Description
Harnessing Endogenous Mechanisms for Targeted Drug Delivery presents a comprehensive exploration of the evolving landscape of targeted drug delivery, emphasizing the strategic utilization of the body's intrinsic biological pathways. This authoritative two-volume reference addresses the critical need for precision in therapeutic delivery, overcoming physiological, anatomical, and immunological barriers through innovative endogenous mechanisms. By integrating foundational concepts with advanced methodologies, the work underscores the transition from traditional passive and active targeting to sophisticated endogenous strategies that enhance drug specificity and efficacy.The text systematically examines the multifaceted challenges inherent in drug delivery, including detailed analyses of in vivo barriers such as the blood-tumor barrier, blood-brain barrier, ocular, pulmonary, and gastrointestinal obstacles, as well as cellular and intracellular impediments. It further elucidates endogenous stimuli-responsive systems, nutrient transporter exploitation, glyco-targeting, and stealth peptide modifications. Comprehensive coverage extends to drug conjugates, protein corona phenomena, and cell-based delivery platforms encompassing stem cells, leukocytes, erythrocytes, and platelets. The series also addresses extracellular vesicles, viral vectors, and plant virus-based carriers, culminating in critical discussions on manufacturing complexities, regulatory considerations, and clinical translation challenges.This definitive resource is indispensable for graduate students, postdoctoral researchers, and professionals in academia and industry engaged in targeted drug delivery research and development. By providing an in-depth understanding of endogenous targeting mechanisms and their translational potential, the book fosters innovation and supports the advancement of precision therapeutics with the goal of improving patient outcomes.- Provides comprehensive insights into endogenous strategies for targeted drug delivery- Highlights innovative techniques like using cells as Trojan Horse-Cloaking Particles- Explores the clinical and commercial translation of these strategies- Offers practical solutions to contemporary challenges in the area- Emphasizes the role of disease-specific stimuli and plasma proteins in drug delivery
Table of Contents
SECTION 1: Delivery challenges and opportunities1. Introduction and impact statement 2. Challenges and opportunities in targeted deliverySECTION 2: Delivery barriers3. Blood—tumor barriers4. The blood—brain barrier5. Overcoming ocular barriers for effective drug delivery6. Pulmonary barriers to targeted delivery7. Exploiting gastrointestinal barriers for targeted drug delivery8. Cellular and intracellular barriers for drug deliverySECTION 3: Endogenous targeting strategies9. Overview of endogenous targeted delivery strategies10. Endogenous pH alterations for precision drug delivery11. Hypoxia responsive delivery systems12. Redox-responsive micellar drug delivery systems13. Nutrient transporter-targeted drug delivery14. Glyco-targeted delivery systems15. Surface-modified delivery systems for stealth functionSECTION 4: Drug conjugates16. Therapeutic exploitation of the neonatal Fc receptor in albumin-based drug designs17. Lectin conjugates for targeted deliverySECTION 5: Protein corona-enabled delivery18. Overview of protein corona formation and implications19. Protein corona-mediated targeted delivery20. Protein corona—enabled cloaking systems for drug delivery21. Harnessing the protein corona for brain targeted deliverySECTION 6: Cell-based drug delivery22. Stem cell-based drug delivery system23. Leukocyte-targeting drug delivery systems24. Large peritoneal macrophage tropism for targeted delivery25. Neutrophil-based drug delivery systems26. Erythrocyte-based delivery27. Platelet-based drug delivery systemsSECTION 7: Cellular "backpacks"28. Cellular backpacks as drug delivery systems29. Immune cell backpacks30. Red blood cell as a hitchhiking platform for targeted systemic drug deliverySECTION 8: Extracellular vesicles31. Extracellular vesicle journey: Cellular secretion, communication, and functions32. Extracellular vesicles for targeted delivery33. Surface-engineered extracellular vesicles34. Role of bacterial extracellular vesicles in health and diseasesSECTION 9: Viral particles for targeted delivery35. Engineered viral vectors as tools for therapeutic gene delivery36. Targeted delivery using virus-like particles37. Engineered plant virusesSECTION 10: Clinical Translation―Challenges and Opportunities38. Manufacturing of complex pharmaceuticals
