Pathophysiology - E-Book（8）

著者名：Banasik PhD, ARNP, Jacquelyn L.

Elsevier（2026/01/23発売）

• 言語：ENG
• ISBN：9780443125232
• eISBN：9780443127700

Description

Gain the in-depth understanding of pathophysiology you need to guide your patient care! Using a systems approach, Pathophysiology, 8th Edition, examines the etiology, pathogenesis, clinical manifestations, and treatment of diseases and disorders. The book begins with a review of normal anatomy and physiology, followed by pathophysiology and application of concepts to specific disorders. Each chapter includes a discussion of the disease processes and abnormalities that may occur, with a focus on the pathophysiologic concepts involved. Written by a team of expert contributors led by Jacquelyn Banasik, this text emphasizes the major pathophysiology concepts relevant to clinical practice while not overwhelming the reader with minute detail.- Clear, easy-to-read writing style emphasizes critical thinking, and includes many tables, boxes, and figures to highlight key content- Thorough updates include information on the newest scientific findings and advances in treatment, more than 100 new figures for improved clarity, and more- More than 1,000 full-color photos and illustrations help to clarify complex pathophysiological concepts- Global Health Care boxes summarize topics such as COVID-19, HIV/AIDS, Ebola, tropical diseases, and more, with information on prevalence, mechanism of disease and transmission- Pediatric and Older Adult Considerations boxes address age-related changes associated with specific body systems- Useful learning resources include chapter outlines, bolded key terms, key questions, Key Points boxes, Clinical Judgment challenges, and chapter summaries- NEW! Updated content throughout the book reflects the latest research and thinking in pathophysiology

Table of Contents

UNIT I Pathophysiologic Processes1 Introduction to PathophysiologyFramework for PathophysiologyConcepts of Normality in Health and DiseaseEpidemiology2 Homeostasis Allostasis and Adaptive Responses to StressorsHomeostasis and AllostasisStress as a ConceptNeurohormonal Mediators of Stress and AdaptationAdaptation Coping and IllnessUNIT II Cellular Function3 Cell Structure and FunctionPlasma MembraneOrganization of Cellular CompartmentsCellular MetabolismFunctions of the Plasma MembraneIntercellular Communication and Growth4 Cell Injury Aging and DeathReversible Cell InjuryCellular AdaptationIrreversible Cell InjuryEtiology of Cellular InjuryAgingSomatic Death5 Genome Structure Regulation and Tissue DifferentiationStructure and Function of Deoxyribonucleic AcidRegulation of the GenomeDifferentiation of Tissues6 Genetic and Developmental DisordersPrinciples of InheritanceGenetic DisordersChromosomal AbnormalitiesMendelian Single-Gene DisordersNonmendelian Single-Gene DisordersPolygenic and Multifactorial DisordersEnvironmentally Induced Congenital DisordersDiagnosis Counseling and Gene Therapy7 NeoplasiaBenign Versus Malignant GrowthEpidemiology and Cancer Risk FactorsGenetic Mechanisms of CancerMultistep Nature of CarcinogenesisInvasion and MetastasisEffects of Cancer On the BodyCancer TherapyUNIT III Defense8 Infectious ProcessesHost-Microbe RelationshipTransmission of InfectionTypes of Pathogenic Organisms9 Inflammation and ImmunityComponents of the Immune SystemEpithelial BarriersMononuclear Phagocyte SystemLymphoid SystemLeukocytesChemical Mediators of Immune FunctionInnate Defenses and InflammationInflammationHealingInflammatory ExudatesSystemic Manifestations of InflammationSpecific Adaptive ImmunityMajor Histocompatibility ComplexAntigen Presentation By Major Histocompatibility ComplexMechanisms of Cell-Mediated ImmunityMechanisms of Humoral ImmunityAntibody StructurePassive and Active ImmunityIntegrated Function and Regulation of the Immune SystemIntegrated Response to Microbial AntigenIntegrated Response to Viral AntigenRegulation of Immune Function10 Alterations in Immune FunctionExcessive Immune ResponsesAutoimmunityHypersensitivityDeficient Immune ResponsesPrimary Immunodeficiency DisordersSecondary Immunodeficiency Disorders11 Malignant Disorders of White Blood CellsClassification of Hematologic NeoplasmsEtiology of Myeloid and Lymphoid NeoplasmsGeneral Principles of ManagementMyeloid NeoplasmsLymphoid Neoplasms12 HIV Disease and AidsEpidemiologyEtiologyPathogenesisDiagnostic TestingMonitoring the Progression of HIVClinical ManifestationsTreatmentUNIT IV Oxygen Transport Blood Coagulation Blood Flow and Blood Pressure13 Alterations in Oxygen TransportComposition of BloodStructure and Function of Red Blood CellsGas Transport and Acid-Base BalanceAnemiaAnemia Related to Decreased Red Cell ProductionAnemia Related to Inherited Disorders of the Red CellAnemia Related to Extrinsic Red Cell Destruction or LossPolycythemia14 Alterations in Hemostasis and Blood CoagulationThe Process of HemostasisEvaluation of Hemostasis and CoagulationVascular and Platelet DisordersCoagulation Disorders15 Alterations in Blood FlowOrganization of the Circulatory and Lymphatic SystemsPrinciples of FlowControl of FlowGeneral Mechanisms that Cause Altered FlowAlterations in Arterial FlowAlterations in Venous FlowAlterations in Lymphatic Flow16 Alterations in Blood PressureArterial Blood PressureMechanisms of Blood Pressure RegulationHypertensionLow Blood PressureUNIT V Cardiac Function17 Cardiac FunctionCardiovascular AnatomyCardiac CycleCoronary CirculationCardiac MyocytesMolecular Basis of ContractionCardiac Energy MetabolismCardiac ElectrophysiologyElectrocardiographyDeterminants of Cardiac OutputEndocrine Function of the HeartTests of Cardiac Function18 Alterations in Cardiac FunctionCoronary Heart DiseaseEndocardial and Valvular DiseasesMyocardial DiseasesPericardial DiseasesCongenital Heart Diseases19 Heart Failure and DysrhythmiasHeart