Description
In this issue of Heart Failure Clinics, guest editor Dr. Ragavendra R. Baliga brings his considerable expertise to the topic of Epigenetics of Heart Failure. Top experts in the field explore how chemical modifications to DNA and histones influence gene expression without altering the genetic code, contributing to the development and progression of heart failure. Factors such as DNA methylation, histone modifications, and non-coding RNAs can regulate key pathways involved in cardiac remodeling, inflammation, and fibrosis. Environmental influences like diet, stress, and toxins can also impact these epigenetic changes, potentially worsening heart function. Understanding these mechanisms may lead to novel therapeutic targets for preventing or treating heart failure at the molecular level.- Contains 18 relevant, practice-oriented topics including DNA damage response in hereditary cardiomyopathies; novel insights from mammals of extreme longevity into genetic and epigenetic regulation of heart regeneration and repair; epigenetic control in clonal hematopoiesis and impact on heart failure; pharmacological and lifestyle interventions to modulate the epigenome in heart failure; epigenetics in dilated cardiomyopathy; and more- Provides in-depth clinical reviews on epigenetics of heart failure, offering actionable insights for clinical practice- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews
Table of Contents
Multiomics Insights into Epigenetic Mechanisms and Their Role as Biomarkers for Acute Coronary SyndromeEpigenetic Therapeutics in Human Heart FailureEpigenetic Regulation in Dilated CardiomyopathyPharmacologic and Lifestyle Interventions to Modulate the Epigenome in Heart FailureThe Pathogenic Role of the DNA Double-Stranded Breaks in Hereditary CardiomyopathiesGenetics of Thoracic and Thoracoabdominal Aortic Dissections and AneurysmsGenetic Determinants of Response to P2Y 12 Inhibitors and Clinical ImplicationsPediatric and Familial Genetic Arrhythmia Syndromes: Evaluation of Bidirectional Ventricular Tachycardia—Differential DiagnosisGenetic Risk Stratification in Arrhythmogenic Left Ventricular CardiomyopathyEmerging Targeted Therapies for Inherited Cardiomyopathies and Arrhythmias
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形而上学の基本（第２版）
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