Description
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer's Disease, Second Edition delves into the complexities of drug discovery, specifically for Alzheimer's Disease, presenting the necessary paradigm for future success in research and treatment. This edition is thoroughly updated with recent developments in therapeutic strategies, including amyloid hypothesis, tau, apo E, insulin, and others, and introduces a new chapter on drug delivery to the brain. Additionally, the book encompasses diagnosis, epidemiology, drug discovery strategies, current therapeutics, and more, offering a comprehensive approach to Alzheimer's Disease.It covers the latest in targeted drug design, preclinical studies, and animal models, making it an essential resource for pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers. Patients and advocacy groups can also gain valuable insights from the overview of current treatments and scientific advancements in the field.- Covers Monoclonal Antibodies approaches- Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders- Explores how in vitro and in vivo models translate to human physiology
Table of Contents
1. Neurodegenerative disorders: why do we need new therapies?2. Cognitive and functional considerations in Alzheimer's disease diagnosis3. National plan and resources to address Alzheimer's disease4. Biosensor approaches in the diagnosis of a neurodegenerative disorder5. Current therapies for the treatment of Alzheimer's disease: small molecules - Acetylcholine esterase inhibitors and NMDA receptor antagonist6. Physicochemical properties for potential AD drugs7. Receptor targets in Alzheimer's disease drug discovery8. Amyloid hypothesis in the development of therapeutic agents for Alzheimer's disease 9: Tau proteins10. Cholesterol and fat metabolism in Alzheimer's disease11. Mitochondria as a therapeutic target for the treatment of Alzheimer's disease12. Peptide-based therapeutics13. Anti-inflammatory and immunomodulating agents14. Prion and other protein folding hypotheses15. Simple in vivo models of Alzheimer's disease16. Rodent models for Alzheimer's disease drug discovery17. Drug delivery to the brain18. Alzheimer's disease drugs in clinical trials19. Biologics for the treatment of Alzheimer's disease20. Brain health21. Non-pharmacologic treatment approaches
