Description
Extracellular Mitochondria in Health and Disease covers this new and significant area of research, shedding light on their roles in intercellular communication and disease pathology. These tiny powerhouses, traditionally known for their intracellular functions, are now recognized for their extracellular activities that impact various physiological and pathological processes. The book delves into a range of topics, including cellular mechanisms of mitochondrial transfer, metabolic signaling, and the crosstalk between extracellular vesicles and mitochondria. It serves as a comprehensive guide for scientists, researchers, and students eager to explore these novel findings and their potential implications.Other sections examine the roles of extracellular mitochondria in immune regulation and inflammation, neurodegeneration and neuroprotection, and their therapeutic potential. By bridging gaps in existing literature, this resource offers up-to-date research and discoveries, providing valuable insights into how extracellular mitochondria could revolutionize medical advancements and improve patient outcomes.- Describes cellular mechanisms of mitochondrial transfer and metabolic signaling- Discusses extracellular mitochondria in health and disease- Explains extracellular mitochondria in immune regulation and inflammation- Explores therapeutic potential of extracellular mitochondria
Table of Contents
Chapter 1. General introductionMarvin EdeasChapter 2. Cellular mechanisms of mitochondrial transfer and metabolicsignaling Beatriz Guedes, Inês Melo-Marques, Ana Raquel Esteves and Sandra Morais CardosoChapter 3. Modern techniques for studying extracellular mitochondriaPasquale D'Acunzo, Efrat Levy and Carla LopesChapter 4. Interplay between extracellular vesicles and mitochondriaPatricia Coelho and Paulo PinheiroChapter 5. Extracellular mitochondria: dual roles in neurodegeneration and neuroprotectionTomas Ferro, Adrián Tejero and Filipe DuarteChapter 6. Extracellular vesicles bearing mitochondria in cardiometabolic diseasesM. Carmen Martinez and Ramaroson Andriantsitohaina RamarosonChapter 7. Therapeutic potential of extracellular mitochondria: applications and challenges Cristina Mas-Bargues, Javier Huete-Acevedo, Marta Arnal-Forné, Sandra Atencia-Rabadán, José de Santiago-Montesinos, Karolina Dorosz and Consuelo BorrásChapter 8. Conclusions and future perspectivesCarla Lopes
