Description
Pharmacology of Ketamine: Fundamentals, Applications, Delivery Systems and Clinical Aspects explores the multifaceted properties of ketamine for diverse applications, delving into dosing strategies, routes of administration, and their pharmacological implications. The book begins with an introduction that underscores the need to bridge research and practice. It then delves into the pharmacological intricacies of ketamine, dissecting mechanisms and dosing strategies and exploring the diverse routes of administration and their impact on ketamine's metabolites.The book then explores the PK and PD characteristics of ketamine, followed by a deep dive into clinical applications emphasizing anesthesia, psychiatric therapy, and emerging treatments. The final part of the book covers addiction, toxicity, and future research perspectives. It will serve as a comprehensive reference tailored to the needs of both researchers and clinicians involved in the administration and study of ketamine.- Summarizes current literature and evidence based research of ketamine from a pharmacological and clinical perspective- Provides an interdisciplinary perspective on the use of ketamine in research and clinical settings- Considers the future research directions of ketamine
Table of Contents
1. Ketamine and its metabolites – mechanism of action2. Ketamine pharmacokinetics and pharmacodynamics3. Ketamine effects on brain dynamics4. Ketamine for depression and other psychiatric diseases 5. Undestanding ketamine subjective effects 6. Ketamine for acute and chronic pain 7. Ketamine for neuropathic pain: animal and human studies8. Ketamine for addiction treatment 9. Cardiorespiratory effects of ketamine10. Ketamine toxicity: translating preclinical findings to adverse effects in humans 11. Recreational use of ketamine12. Ketamine in the era of the opioid crisis13. Future Perspectives
