医薬エピジェネティクス（第２版） Pharmacoepigenetics（2）

著者名：Cacabelos, Ramón (EDT)

Academic Press（2025/07/18発売）

• 言語：ENG
• ISBN：9780443187223
• eISBN：9780443187230

Description

Pharmacoepigenetics, Second Edition, a volume within the Translational Epigenetics series, is a comprehensive reference on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible view of the field, from basic principles to applications in disease therapeutics. Leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine.The new edition has been fully revised to address recent advances in epigenetics, from new natural and synthetic compounds with epigenetic effects to the role of epigenetics in the pathogenesis of a growing number of complex diseases, including further cancers, cardiovascular disorders, and brain disorders. Newly identified molecular components in the functional architecture of the epigenetic machinery, as well as practical and relevant pharmacoepigenetics topics related to COVID-19 and other world health challenges, are also discussed. Each chapter has been updated to include a chapter summary, keywords and definitions, and further color figure and charts for learning reinforcement, along with clinical research case studies illustrating key research in the field and making findings and research approaches more actionable for readers.- Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development- Features chapter contributions from leading international researchers in academia, clinical settings, and the pharmaceutical industry- Instructs researchers, students, and clinicians in better interpreting and employing pharmacoepigenetics in drug development, efficiency, and safety- Incorporates recent advances, including epigenetic drugs and biomolecules with epigenetic effects in cancer, cardiovascular disorders, brain disorders, and COVID-19- Includes chapter definitions, key words, and summaries to reinforce understanding, as well clinical research case studies illustrating key research in the field

Table of Contents

I. General Principles1.The Epigenetic Machinery in the Life Cycle2. Pharmacoepigenetics: Basic Principles for Personalized Medicine3. Pharmacoepigenetic Processors4. Epigenetic regulation of genes involved in drug metabolism5. MicroRNA-Dependent Gene Regulation of the Human Cytochromes P4506. Epigenetic regulation of transporter genes7. Pathoepigenetics: The Role of Epigenetic Biomarkers in Disease PathogenesisII. Drug Development and Drug-related events8. Epigenetic Drugs9. Pharmacoepigenetics of Novel Nucleoside DNA Methyltransferase Inhibitors10. Pharmacoepigenetics: Novel Mechanistic Insights in Drug Discovery and Development Targeting Chromatin-Modifying Enzymes11. Pharmacoepigenetics of EZH2 Inhibitors12. Regulators of Histone Acetylation: Bromodomain Inhibitors13. Bromodomain Inhibition and Its Application to Human Disease14. Pharmacoepigenetics of Brassica-Derived Compounds15. Pharmacological Nicotinamide: Mechanisms Centered Around SIRT1 Activity16. Epigenetic-related Drug Resistance17. ToxicoepigeneticsIII. Pharmacoepigenetics of Cancer18. Epigenetics of Aging and Cancer: A Comprehensive Look19. Epigenetic Drug Discovery for Cancer20. Pharmacoepigenetics of Histone Deacetylase Inhibitors in Cancer21. Pharmacoepigenetics of LSD1 Inhibitors in Cancer22. Epigenetic effects of AntiGan in Cancer23. Pharmacoepigenetic Considerations for the Treatment of Breast Cancer24. Pharmacoepigenetics of Acute Myeloid Leukemia25. Therapeutic Potential of Pharmacoepigenetics in Cholangiocarcinoma26. Pharmacoepigenetics of Gastrointestinal disorders and Cancer27. Pharmacoepigenetics of Chinese Herbal Components in CancerIV. Pharmacoepigenetics of Cardiovascular disease and Related disorders28. Epigenetics and Pharmacoepigenetics of myocardial infarction29. Epigenetics and Pharmacoepigenetics of Arteriosclerosis30. Epigenetics and Pharmacoepigenetics of Hypertension31. Pharmacoepigenetics of Ancoagulants32. Epigenetics in Doxorubicin Cardiotoxicity33. Epigenetic effects of CardioSar in cardiovascular disordersV. Pharmacoepigenetics of Central Nervous System disorders34. Epigenetics and Pharmacoepigenetics of Neurodevelopmental and Neuropsychiatric Disorders35. Pharmacoepigenetics and Toxicoepigenetics in Neurodevelopmental Disorders36. Pharmacoepigenetics of Autism Spectrum Disorder37. Pharmacoepigenetics of Antipsychotic Drugs38. Pharmacoepigenetics of Bipolar Disorder39. Pharmacoepigenetics of Major Depression40. Epigenetics and Pharmacoepigenetics of Vestibulocochlear disorders41. Epigenetics and Pharmacoepigenetics of Visual disorders42. Epigenetics and Pharmacoepigenetics of Age-Related Neurodegenerative Disorders43. Epigenetic effects of Nosustrophine in Alzheimer's disease44. Epigenetic effects of Atremorine in Parkinson's disease45. Pharmacoepigenetics and Pharmacoepigenomics of Valproate in Neurodegenerative Disease46. Pharmacoepigenetics of Memantine in DementiaVI. Pharmacoepigenetics of Metabolic and Endocrine disorders47. Pharmacoepigenetics in Type 2 Diabetes Mellitus48. Epigenetics and Pharmacoepigenetics of hypercholesterolemia and lipid metabolism disorders49. Pharmacoepigenetics of Statins50. Epigenetics and Pharmacoepigenetics of Thyroid disordersVII. Pharmacoepigenetics of Immunological and Inflammatory disorders51. Pharmacoepigenetics of Immunological Disorders52. Pharmacoepigenetics of Rheumatic Disorders53. Epigenetics and Pharmacoepigenetics of Skin disorders54. Pharmacoepigenetics of Systemic Lupus ErythematosusVIII. Nutritional Epigenetics55. Nutriepigenetics56. Epinutraceuticals: Novel biomolecules with epigenetic effectsIX. Epigenetics and Pharmacoepigenetics of infectious disorders57. Pharmacoepigenetic of bacterial infections58. Pharmacoepigenetics of viral infections59. Pharmacoepigenetics of COVID-19X. Mendelian epigenetic disorders60. Pharmacoepigenetics of Mendelian disorders associated with the epigenetic machinery