Description
Therapeutics of Natural and Synthetic Compounds in Protease Induced Cancer presents a detailed discussion on the role of therapeutic and synthetic compounds in proteases and how they have been utilized to develop anticancer drugs, covering both their structure and functions. In addition, the book explores the experimental and theoretical aspects of natural and synthetic compound design based on proteases. Sections bridge the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.In 23 chapters, this book gives both insights on the general aspects of the role of natural and synthetic compounds in cancer therapeutics, in cancer development, treatment, and their use in clinical trails. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers in oncology and for those working to identify targets for drug development.- Discusses natural and synthetics compounds as promising targets for future research since they play a pivotal role in cancer progression and response to chemotherapy treatment- Provides insights into the multifaceted role of natural and synthetic compounds in regulating many important cell processes, including cell proliferation, apoptosis, and autophagy- Discusses the key role of compounds in cancer progression, focusing on the status of natural, chemically modified, and synthetic inhibitors in various types of malignancies
Table of Contents
A. General Aspects1. Therapeutic aspects of urokinase-plasminogen activator system in cancer2. The role of acetylcholinesterase in cancer development and possible therapeutic applications by natural and synthetic compounds.3. Influence of serine proteases on bone morphogenetic proteins: Insights for advancing treatment paradigm in breast cancer4. Structural insights of proteases in cancer therapy perspectivesB. Role of Synthetic Compounds5. Role of Boron containing synthetic compounds as serine proteases inhibitors in prostate cancer6. Exploring Synthetic and Natural Compounds for Cathepsin B-mediated Breast Cancer: Mechanisms and Therapy ResponsesC. Role of Natural Compounds7. Flavonoids containing phytochemicals as protease inhibitors in cancer chemoprevention8. Dietary proteases and their connection to cancer9. Natural compounds as potential cancer therapeutics: A focus on curcumin and resveratrol10. Snake venom proteases as potential cancer therapeutics11. Autophagy Inhibition with Plant-Derived Alkaloids in Cancer Treatment: From Molecular Mechanisms to Targeted Therapy12. From Naturally-sourced aspartic and metalloproteases inhibitors to therapeutic aspects of skin cancer13. Compounds of plant origin as therapeutics for serine protease implicated in colorectal cancer14. Plant peptides and proteins as protease inhibitors in breast cancer therapy15. Exploring the Potentials of Genistein, Lycopene, Ellagic acid as Protease Inhibitors in Cancer Therapeutics16. Modulation of serine proteases in liver cancer by quercetin - a therapeutic perspective17. Role of natural bioactive small molecules as inhibitors for cysteine proteases in cancer18. Natural compounds as inhibitors of MMPs19. A Comprehensive Overview of Epigallocatechin Gallate and Its Role in Human Osteosarcoma inhibition.20. Exploring the natural repository of serine protease inhibitors for cancer therapeuticsD. Protease inhibitors in Clinical Trials21. Inhibitors of matrix metalloproteinases in clinical trials22. Breast cancer therapeutics by protease inhibitors23. Clinical trials on the efficacy of anticancer protease inhibitors on breast, prostate, lung
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