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Description
This volume brings together a series of review articles that highlight new advances in using the fruit fly, Drosophila melanogaster, to study a wide range of cancer-related topics. Building on the foundation of Volume I, the articles demonstrate how research in Drosophila continues to uncover important developmental, cellular, and molecular mechanisms underlying tumor growth, progression, and systemic interactions.
Readers will appreciate how the fly’s simple genetics and powerful experimental tools make it a flexible and effective model for studying cancer. Drosophila offers unique opportunities to answer key questions about how uncontrolled cell proliferation begins and progresses into cancer—questions that can be very difficult to explore in other systems.
This book is a valuable resource for researchers interested in using the Drosophila model to better understand cancer biology and to help find new strategies to combat this disease.
Table of Contents
Chapter 1. Unveiling the Tumor Suppressors: Insights from Drosophila.- Chapter 2. Notch signaling in Drosophila tumor models.- Chapter 3. Non-autonomous Regulation of Tumor Growth.- Chapter 4. Transcriptional Regulation of Lipid Metabolism by Wnt Signaling and Hox Protein Cues. - Chapter 5. The power of Drosophila in Modeling Cancer Cachexia.- Chapter 6. Drosophila Intestine as a Model to Study Tumors.- Chapter 7. Host-microbe Interactions in Drosophila Cancer.- Chapter 8. Drosophila as a Model for Metastasis.- Chapter 9. Epigenetic regulation in Drosophila Tumor Models.- Chapter 10. From the Making of a neural lineage to the Making of a Tumor: Lessons from the “simple” Drosophila Brain.- Chapter 11. Drosophila Melanogaster as a Model System for Human Glioblastoma.- Chapter 12. Translationally Controlled Tumor Protein (Tctp) and Growth Regulation in the Drosophila model.- Chapter 13. Modelling Cancer in Drosophila: Exploration to Personalised Medicine.- Chapter 14. SVC112; from hummingbirds to Head and Neck Cancer.
