Description
Comprehensive coverage of major families of viruses, including human pathogens and viruses of organisms from bacteria to plants, with updated information on antiviral drugs, vaccines, antiviral immunity, and gene therapy
Fundamentals of Molecular Virology is a textbook designed for university students learning about viruses at the undergraduate or graduate levels. Chapters contributed by prominent virologists cover many of the major virus families. Each chapter is designed to tell a story about the viruses covered, including information on discovery, diseases and pathogenesis, virus structure, steps in replication, and interaction with cellular signaling pathways. This approach portrays the "personality" of each virus, helping students to learn the material and build up their knowledge of virology starting with smaller and simpler viruses and proceeding to more complex viruses.
Major importance is given to viruses that infect humans and cause disease, but coverage is broad, including viruses of bacteria, Archaea, algae, invertebrates, and plants. Information boxes highlight applications and research directions of particular significance. Chapters conclude with sections presenting fundamental concepts, review questions, and lists of key terms, which are defined in a glossary at the end of the book.
This 3rd edition of Fundamentals of Molecular Virology includes detailed information on the recent COVID-19 pandemic and mRNA vaccine technology, additional sections on pathogenic herpesviruses, and updates on recent outbreaks of Zika virus, Ebola virus and mpox diseases. New chapters describe hepatitis C virus, rhabdoviruses, viruses of invertebrates, oncolytic viruses, and virus-mediated gene therapy. All chapters, including those on innate and adaptive immune responses to virus infections, virus vaccines, and antiviral agents, were revised and updated.
Table of Contents
Section I: Introduction to Virology
1. Introduction to Virology 2
Nicholas H. Acheson, McGill University
Christopher D. Richardson, Dalhousie University
2. Virus Structure and Assembly 19
Stephen C. Harrison, Harvard University
3. Virus Classification: The World of Viruses 32
Nicholas H. Acheson, McGill University
Christopher D. Richardson, Dalhousie University
4. Virus Entry 47
Ari Helenius, Swiss Federal Institute of Technology, Zurich
Section II: Viruses of Bacteria and Archaea
5. Single-Stranded RNA Bacteriophages 60
Jan van Duin, University of Leiden
Karthik Chamakura, Armata Pharmaceuticals, Inc., Los Angeles
Ryland Young, Texas A&M University
6. Microviruses 74
Bentley A. Fane, University of Arizona
Aaron P. Roznowski, University of Arizona
7. Bacteriophage T7 84
William C. Summers, Yale University
Ian J. Molineux, University of Texas, Austin
8. Bacteriophage T4 94
Deborah M. Hinton, National Institutes of Health, Bethesda
Eric S. Miller, North Carolina State University
9. Bacteriophage Lambda 110
Michael Feiss, University of Iowa
10. Viruses of Archaea 123
David Prangishvili, Institut Pasteur, Paris Mart Krupovic, Institut Pasteur, Paris
Section III: Positive-Strand RNA Animal Viruses
11. Picornaviruses 140
Bert L. Semler, University of California, Irvine
12. Flaviviruses 152
Richard Kuhn, Purdue University
Shelton Bradrick, Trudeau Institute, New York
13. Hepaciviruses 164
John Lok Man Law, Memorial University of Newfoundland
Michael Houghton, University of Alberta
14. Togaviruses and Rubella Virus 178
Anil Kumar, University of Saskatchewan
Milton Schlesinger, Washington University, St. Louis
Sondra Schlesinger, Washington University, St. Louis
Tom C. Hobman, University of Alberta
15. Coronaviruses 192
Marc Desforges, Ste. Justine Hospital, Université de Montréal
Pierre Talbot, Institut Armand-Frappier
Mark Denison, Vanderbilt University
Section IV: Negative-Strand and Double-Stranded RNA Animal Viruses
16. Paramyxoviruses and Pneumoviruses 210
Nicholas H. Acheson, McGill University
Daniel Kolakofsky, University of Geneva
Laurent Roux, University of Geneva
Christopher D. Richardson, Dalhousie University
17. Rhabdoviruses 226
Valery Grdzelishvili, University of North Carolina, Charlotte
Cassandra A. Catacalos, University of North Carolina, Charlotte
18. Filoviruses 237
Heinz Feldmann, Rocky Mountain Laboratories, Montana
Hans-Dieter Klenk, University of Marburg
Nicholas H. Acheson, McGill University
Angela Rasmussen, University of Saskatchewan
19. Bunyaviruses 251
Richard M. Elliott, University of Glasgow
Lev Levanov, University of Helsinki
Alexander Plyusnin, University of Helsinki
20. Influenza Viruses 262
Dalius J. Briedis, McGill University
Alyson Kelvin, University of Calgary
21. Reoviruses 278
Kristen M. Ogden, Vanderbilt University
Terence S. Dermody, University of Pittsburgh School of Medicine
Section V: Small DNA Animal Viruses
22. Parvoviruses 292
Peter Beard, École Polytechnique Fédérale de Lausanne
Sarah Wootton, University of Guelph
23. Polyomaviruses 302
Nicholas H. Acheson, McGill University
James A. DeCaprio, Dana-Farber Cancer Institute, Harvard University
24. Papillomaviruses 318
Greg Matlashewski, McGill University
Lawrence Banks, International Centre for Genetic Engineering and Biotechnology, Trieste
Miranda Thomas, International Centre for Genetic Engineering and Biotechnology, Trieste
Section VI: Large DNA Animal Viruses
25. Adenoviruses 330
Philip Branton, McGill University
Richard C. Marcellus, McGill University
Luca D. Bertzbach, Leibniz Institute of Virology, Hamburg
Thomas Dobner, Leibniz Institute of Virology, Hamburg
26. Herpesviruses 344
Bernard Roizman, University of Chicago
Gabriella Campadelli-Fiume, University of Bologna
Richard Longnecker, Northwestern University
Bruce Banfield, Queens University
Craig McCormick, Dalhousie University
27. Poxviruses 366
Richard Condit, University of Florida
Matthew D. Gresseth, Medical University of South Carolina
Paula Traktman, Medical University of South Carolina
Section VII: Viruses with a Reverse Transcriptase
28. Retroviruses 382
Alan Cochrane, University of Toronto
29. Human Immunodeficiency Virus 394
Alan Cochrane, University of Toronto
30. Hepadnaviruses 406
Christopher D. Richardson, Dalhousie University
William Addison, University of Alberta D.
Lorne Tyrrell, University of Alberta
Section VIII: Viroids and Prions
31. Viroids and Hepatitis Delta Virus 420
Jean-Pierre Perreault, Université de Sherbrooke
Martin Pelchat, University of Ottawa
Charith Raj Adkar-Purushothama, Université de Sherbrooke
32. Prions 431
Dalius J. Briedis, McGill University
David Westaway, University of California, San Francisco
Section IX: Viruses of Plants, Algae, and Invertebrates
33. Cucumber Mosaic Virus 444
Marilyn J. Roossinck, Pennsylvania State College of Agricultural Sciences
34. Viruses of Algae and Mimivirus, a Giant Virus 457
Michael J. Allen, University of Exeter
William H. Wilson, Marine Biological Association, Plymouth
John A. Duffy, University of Exeter
35. Baculoviruses 478
Eric Carstens, Queens University
Robert L. Harrison, U.S. Department of Agriculture, Beltsville, Maryland
36. Viruses of Invertebrates 489
Peter Krell, University of Guelph
Section X: Host Defenses Against Virus Infection
37. Innate Immune Responses Against Virus Infection 506
Karen Mossman, McMaster University
John Hiscott, Istituto Pasteur-Fondazione Cenci Bolognetti, Rome
Alessandra Zevini, Istituto Pasteur-Fondazione Cenci Bolognetti, Rome
38. Adaptive Immune Responses to Virus Infection 527
Malcolm G. Baines, McGill University
Karen Mossman, McMaster University
Naglaa Shoukry, University of Montreal
Section XI: Medical Applications of Virology
39. Antiviral Vaccines 542
Brian Ward, McGill University
Hilary E. Hendin, McGill University
40. Antiviral Chemotherapy 562
Donald M. Coen, Harvard Medical School
41. Oncolytic Viruses 578
Vishnupriyan Kumar, Dalhousie University
Liang-Tzung Lin, Taipei Medical University
Shashi Gujar, Dalhousie University
42. Virus-Mediated Gene Therapy 586
Richard Peluso, Renovacor, Philadelphia
Christopher D. Richardson, Dalhousie University
