Neurobiology of Mental Illness（4）

著者名：Charney, Dennis S. (EDT)/Buxbaum, Joseph D. (EDT)/Sklar, Pamela (EDT)/Nestler, Eric J. (EDT)

Oxford University Press（2013/06/25発売）

• 言語：ENG
• eISBN：9780190240813

Description

Our understanding of the neurobiological basis of psychiatric disease has accelerated in the past five years. The fourth edition of Neurobiology of Mental Illness has been completely revamped given these advances and discoveries on the neurobiologic foundations of psychiatry. Like its predecessors the book begins with an overview of the basic science. The emerging technologies in Section 2 have been extensively redone to match the progress in the field including new chapters on the applications of stem cells, optogenetics, and image guided stimulation to our understanding and treatment of psychiatric disorders. Sections' 3 through 8 pertain to the major psychiatric syndromes-the psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood-onset. Each of these sections includes our knowledge of their etiology, pathophysiology, and treatment. The final section discusses special topic areas including the neurobiology of sleep, resilience, social attachment, aggression, personality disorders and eating disorders. In all, there are 32 new chapters in this volume including unique insights on DSM-5, the Research Domain Criteria (RDoC) from NIMH, and a perspective on the continuing challenges of diagnosis given what we know of the brain and the mechanisms pertaining to mental illness. This book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. In doing so it translates information from the basic laboratory to the clinical laboratory and finally to clinical treatment. No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text. The result is an excellent and cutting-edge resource for psychiatric residents, psychiatric researchers, doctoral students, and postdoctoral fellows the neurosciences.

Table of Contents

Table of ContentsContributorsPrefaceSECTION I: Introduction to Basic NeuroscienceEric J. Nestler1. Overview of Brain DevelopmentJohn L. R. Rubenstein2. Neurochemical Systems in the Central Nervous SystemAriel Y. Deutch and Robert H. Roth3. Principles of Electrophysiology Evelyn K. Lambe4. Principles of Signal TransductionJean-Antoine Girault and Paul Greengard5. Synaptic and Neural PlasticitySaïd Kourrich and Antonello Bonci6. Principles of Molecular BiologySteven E. Hyman and Eric J. Nestler7. Epigenetics of Psychiatric Diseases Bryan E. McGill and Huda Y. ZoghbiSECTION II: New Methods and New Technologies for Preclinical and Clinical NeurobiologyKarl Deisseroth8. Transgenic Tools and Animal Models of Mental Illness Lisa M. Monteggia, William Carlezon, Jr. and Ralph J. DiLeone9. Application of Stem Cells to Understanding Psychiatric DisordersKimberly M. Christian, Hongjun Song and Guo-li Ming10. Optogenetic Technologies for Psychiatric Disease Research: Current Status and ChallengesLief E. Fenno and Karl Deisseroth11. Blood-Brain Barrier Opening and Drug Delivery Using Focused Ultrasound and MicrobubblesElisa E. Konofagou12. Genetic Methodologies and ApplicationsShaun M. Purcell13. The Brain and Its EpigenomeAmanda C. Mitchell, Yan Jiang, Cyril J. Peter, Ki A. Goosens and Schahram Akbarian14. Network Methods for Elucidating the Complexity of Common Human Diseases Eric E. Schadt15. Brain Imaging Methodologies Hanzhang Lu, Yihong Yang and Peiying Liu16. Image-Guided Brain Stimulation Mark S. George, John J. Taylor and Jaimie M. HendersonSECTION III: Psychotic DisordersPamela Sklar17. Diagnosis of the PsychosesLianne Morris Smith, Julie W. Messinger and Dolores Malaspina18. Genetics of Schizophrenia and Bipolar Disorder Pamela Sklar19. Genomic Syndromes in Schizophrenia: Overlapping Phenotypes George Kirov, Michael O'Donovan and Michael J. Owen20. Neuroimaging of Psychotic DisordersStephan Heckers, Neil Woodward and Dost Öngür21. Cognitive and Motivational Neuroscience of Psychotic Disorders Alan Anticevic, Erin C. Dowd and Deanna M. Barch22. Mouse Models of Schizophrenia and Bipolar DisorderMikhail V. Pletnikov and Christopher A. Ross23. Cortical GABA Neurons in SchizophreniaAllison A. Curley and David A. Lewis24. Synaptic Disease in Psychiatry Seth G. N. Grant25. Neurodevelopment and SchizophreniaEster J. Kwon, Takahiro Soda and Li-Huei Tsai26. Psychosis PronenessRaquel E. Gur27. Psychotic Disorders: Neurochemistry and PharmacotherapyCarol A. Tamminga and Elena I. Ivleva28. The Neurobiology of Bipolar DisorderKatherine E. Burdick, Stephen J. Haggarty, and Roy PerlisSECTION IV: Mood DisordersHelen S. Mayberg29. The Diagnosis of Mood Disorders Jan Fawcett and Brant Hager30. Genetics of DepressionDouglas F. Levinson31. Animal Models of Mood DisordersGeorgia E. Hodes and Scott J. Russo32. Molecular and Cellular Pathogenesis of Depression and Mechanisms for Treatment ResponseRonald S. Duman33. Pathogenesis of Depression: Clinical StudiesMaura A. Furey, Daniel C. Mathews and Carlos A. Zarate Jr.34. Neural Circuitry of DepressionJoseph L. Price and Wayne C. Drevets35. Neurobiology of Depression in Later Life: Anatomy of MelancholiaK. Ranga Rama Krishnan36. Gonadal Steroids and Mood DisordersDavid R. Rubinow, Peter J. Schmidt and Claire D. Craft37. Depression and Medical IllnessTami D. Benton, Joshua Blume, Paul Crits-Christoph, Benoit Dube and Dwight L. Evans38. Treatments for DepressionDan V. Iosifescu, James W. Murrough and Dennis S. CharneySECTION V: Anxiety DisordersKerry J. Ressler39. Diagnosis of Anxiety DisordersMeghan E. Keough, Murray B. Stein and Peter P. Roy-Byrne40. Genetics of Anxiety DisordersJavier A. Perez, Takeshi Otowa, Roxann Roberson-Nay and John M. Hettema41. The Neurobiology of Fear and Anxiety: Contributions of Animal Models to Current UnderstandingChristopher K. Cain, Gregory M. Sullivan and Joseph E. LeDoux42. Differential roles of GABA Receptors in Anxiety Hanns Möhler43. Prefrontal Cortex Regulation of Emotion and AnxietyBronwyn M. Graham and Mohammed R. Milad44. Developmental Components of Fear and Anxiety in Animal ModelsSiobhan S. Pattwell, Anne-Marie Mouly, Regina M. Sullivan and Francis S. Lee45. Functional Neurocircuitry and Neuroimaging Studies of Anxiety DisordersMadeleine S. Goodkind, Anett Gyurak and Amit Etkin46. Novel Treatment Approaches for Anxiety DisordersAnita Van Zwieten, Gail A. Alvares and Adam J. Guastella47. Pharmacotherapy of Anxiety DisordersJames W. Murrough, Dan V. Iosifescu, and Dennis S. Charney48. Neurobiology and Treatment of OCDSusanne E. Ahmari and H. Blair Simpson49. Neurobiology and Treatment of PTSDKaren E. Murray, Orion P. Keifer, Jr., Kerry J. Ressler, Seth Davin Norrholm and Tanja JovanovicSECTION VI: Substance Use DisordersAntonello Bonci and Nora D. Volkow50. Animal Models of AddictionRafael Maldonado, J. David Jentsch, Brigitte L. Kieffer, and Christopher J. Evans51. Cellular and Molecular Mechanisms of AddictionKathryn J. Reissner and Peter W. Kalivas52. The Genetic Basis of Addictive DisordersDavid Goldman53. Brain Development and the Risk for Substance AbuseKristina Caudle and BJ Casey54. Molecular Imaging in Addictive DisordersChelsea L. Robertson, Steven M. Berman and Edythe D. London55. Brain, Reward, and Drug AddictionVani Pariyadath, Martin P. Paulus and Elliot A. Stein56. Magnetic Resonance Spectroscopy Studies in Substance AbusersLinda Chang, Christine C. Cloak and John L. Holt57. Pharmacotherapy of Substance Use DisordersJane B. Acri and Phil Skolnick58. Epidemiology of Substance Use DisordersDenise B. Kandel, Mei-Chen Hu and Pamela C. GrieslerSECTION VII: DementiaDavid M. Holtzman59. Clinical and Neuropsychological Features of Alzheimer's DiseaseJason Hassenstab, Jeffrey Burns and John C. Morris60. The Genetics of Alzheimer's DiseaseRudolph E. Tanzi61. Experimental Animal Models of Alzheimer's DiseaseDave Morgan62. Structural, Functional and Molecular Neuroimaging Biomarkers for Alzheimer's DiseaseJames B. Brewer, Jorge Sepulcre and Keith A. Johnson63. Fluid Biomarkers for Alzheimer's DiseaseAnne M. Fagan64. Current Therapies for Alzheimer's DiseaseMary Sano and Judith A. Neugroschl65. Disease-Modifying Therapies for Alzheimer's DiseaseJoshua D. Grill and Jeffrey Cummings\66. Lewy Body DementiasStella Karantzoulis and James E. Galvin67. Clinical Features and Pathogenesis of FTDGeorges Naasan and Bruce Miller68. Pathogenesis, Diagnosis and Treatment of Vascular and Mixed DementiasHelena Chang Chui69. Clinical Features and Pathogenesis of Prion DiseaseJoel C. Watts and Michael D. GeschwindSECTION VIII: Psychiatric Disorders of Childhood OnsetJoseph D. Buxbaum70. Epidemiology of Neuropsychiatric and Developmental Disorders of ChildhoodElise B. Robinson, Benjamin M. Neale and Mark J. Daly71. Rare Variants of Substantial Effect in Psychiatric Disorders of Childhood OnsetHeather C. Mefford72. Epigenetics in Early Life ProgrammingTracy L. Bale73. Animal Models in Psychiatric Disorders of Childhood OnsetRichard Paylor, Alexia M. Thomas, Surabi Veeraragavan and Shannon M. Hamilton74. Neuropathology and Synaptic Alterations in Neurodevelopmental DisordersMara Dierssen and Salvador Martínez75. Functional Connectivity: Application to Developmental DisordersLuke Bloy, Ragini Verma and Timothy P.L. Roberts76. Intellectual Disability SyndromesCharles E. Schwartz, Fiorella Gurrieri and Giovanni Neri77. Autism Spectrum DisordersAlexander Kolevzon, A. Ting Wang, David Grodberg and Joseph D. Buxbaum78. Neurobiology of Attention Deficit Hyperactivity DisorderStephen V. Faraone and Joseph Biederman79. Tourette Syndrome and Tic DisordersKyle Williams, Michael H. Bloch, Matthew W. State and Christopher Pittenger80. Novel Therapeutics in Childhood Onset Psychiatric DisordersDorothy E. Grice, Alexander Kolevzon, Walter E. Kaufmann and Joseph D. BuxbaumSECTION IX: Special Topic AreasDennis S. Charney81. DSM-5 Overview and GoalsDavid J. Kupfer and Susan K. Schultz82. The Infirmities of Psychiatric DiagnosisSteven E. Hyman83. Toward Precision Medicine in Psychiatry: The NIMH Research Domain Criteria ProjectBruce N. Cuthbert and Thomas R. Insel84. The Neurobiology of Personality Disorders: The Shift to DSM-5M. Mercedes Perez-Rodriguez, Antonia S. New and Larry J. Siever85. The Neurobiology of AggressionR. James R. Blair86. Neurobiology of Social AttachmentAdam S. Smith, Kelly Lei and Zuoxin Wang87. The Neurobiology of SleepGiulio Tononi and Chiara Cirelli88. The Neurobiology of ResilienceAdriana Feder, Margaret Haglund, Gang Wu, Steven M. Southwick and Dennis S. Charney89. The Neurobiology of Eating DisordersThomas B. Hildebrandt and Amanda DowneyIndex