Bacterial Enzymes as Targets for Drug Discovery : Meeting the Challenges of Antibiotic Resistance

著者名：Kaur, Punit (EDT)/Sharma, Priyanka (EDT)

Academic Press（2024/11/27発売）

• 言語：ENG
• ISBN：9780443222221
• eISBN：9780443222214

Description

Bacterial Enzymes as Targets for Drug Discovery: Meeting the Challenges of Antibiotic Resistance addresses the gap between medical microbiology, structural biology, and genomic science in the development of new antibacterial drug development. This book consolidates detailed profiling of bacterial target enzyme families for the drug discovery process and methodologies for use and validation of the potential drug targets. The contents cover the foundations of the antibiotic drug discovery process and focus on bacterial enzymes as drug targets, building across these disciplines to provide a comprehensive resource in bacterial structural biology and genomics. This is the ideal reference for antibiotic drug discovery researchers in the pharma industry and academia. Biochemists, microbiologists, and medicinal chemists will also benefit from this books' content.- Provides strategies and approaches to drug design aiming at overcoming antibiotic resistance.- Includes most common roadblocks in identifying novel drug targets and presents the strategies to overcome.- Provides potential methods to identify new drug targets by genome mining.

Table of Contents

Part I Primer of antibiotic discovery process1. Antibacterial drug discovery: A Silent Pandemic2. Current scenario and future prospective of drug discovery and development against bacterial enzymes3. Clinical diagnostics of bacterial infections and their resistance to Antibiotics — Current State and Novel Enabling Technologies Implementation Perspectives4. An Odyssey into Phylogenetic Functional Conservation of Novel Antibacterial Targets in Human Pathogens5. Validation of drug targets using molecular methodologies and enzymatic activity assays for validation of inhibitory potential6. Computational tools to identify potential drug targets in bacteria7. Antimicrobial drug resistance and bypassing strategiesPart II Bacterial enzyme as drug targets8. Designing Tomorrow's Antibiotics: Cutting-Edge Strategies and Technologies9. Inhibiting the replication by targeting topoisomerases10. Role of beta lactamases in antibiotic drug discovery11. Selective vs broad spectrum inhibition of novel outer membrane targets in Gram negatives12. Ribosomal binding antibacterial agents13. RNA polymerase: A key target for Novel Antimicrobial Therapeutic Strategies14. Colistin resistance and strategies against superbug, where we are?15. Deoxythymidine pathway enzymes as an antibacterial target16. Arresting the peptidoglycan synthesis to kill the bacteria17. Clp protease complex as a therapeutic target for tuberculosis18. PlaF: a bacterial Lands cycle phospholipase A mediating membrane phospholipid degradation and virulence adaptation19. Bacterial TIR domain-containing proteins as drug targets20. Drug Repurposing: Tackling the antibiotic resistance with existing therapeutics